Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes (Q42488159)

1 November 2017

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes. (English)

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Z Asghar

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author name string

D Yau

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F Chan

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D Leroith

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C B Chan

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15 December 2005

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49

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1

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90-99

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https://scigraph.springernature.com/pub.10.1007/s00125-005-0045-y

1 November 2017

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cites work

Glucagon and regulation of glucose metabolism

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Crossref

https://api.crossref.org/works/10.1007%2FS00125-005-0045-Y

Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes.

21 January 2018

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12 December 2020

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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12 December 2020

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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12 December 2020

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

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12 December 2020

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

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12 December 2020

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

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12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

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12 December 2020

Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice

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12 December 2020

Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians.

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12 December 2020

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

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12 December 2020

Insulin feedback action on pancreatic beta-cell function

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12 December 2020

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

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12 December 2020

Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6.

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12 December 2020

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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12 December 2020

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance

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12 December 2020

Disruption of IRS-2 causes type 2 diabetes in mice

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12 December 2020

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

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12 December 2020

Role of brain insulin receptor in control of body weight and reproduction

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12 December 2020

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

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12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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12 December 2020

Is insulin resistance the principal cause of type 2 diabetes?

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12 December 2020

Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice

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12 December 2020

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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12 December 2020

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

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12 December 2020

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes

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12 December 2020

Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

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12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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12 December 2020

A role for hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in hormone-sensitive lipase-deficient mice.

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12 December 2020

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

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12 December 2020

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes

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12 December 2020

Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice

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12 December 2020

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

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12 December 2020

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

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12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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12 December 2020

10.1007/S00125-005-0045-Y

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DOI

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1 November 2017

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