Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes (Q34818981)

4 August 2017

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title

Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes (English)

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4 August 2017

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2

Issei Komuro

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4 August 2017

Tohru Minamino

1

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ORCID Public Data File 2021

publication date

2 September 2008

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Nature Clinical Practice Cardiovascular Medicine

4 August 2017

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4 August 2017

5

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4 August 2017

637-648

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4 August 2017

10

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Hutchinson-Gilford progeria syndrome: review of the phenotype.

4 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

Ink4a/Arf expression is a biomarker of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Age-dependent impairment of reendothelialization after arterial injury: role of vascular endothelial growth factor.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Vascular cell senescence: contribution to atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Stem cells and the regeneration of the aging cardiovascular system

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Genetic effects on the longevity of cultured human fibroblasts. II. DNA repair deficient syndromes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

The endothelium of advanced arteriosclerotic plaques in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomeres and human disease: ageing, cancer and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

DNA damage foci at dysfunctional telomeres

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Cellular senescence in aging primates.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere length and replicative aging in human vascular tissues

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Age dependent aneuploidy and telomere length of the human vascular endothelium

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere shortening in human coronary artery diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Mechanisms of telomerase induction during vascular smooth muscle cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Human endothelial cell life extension by telomerase expression

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomerized human microvasculature is functional in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Mice Deficient in Telomerase Activity Develop Hypertension Because of an Excess of Endothelin Production

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Arterial aging: is it an immutable cardiovascular risk factor?

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Aging and genome maintenance: lessons from the mouse?

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Modulation of mammalian life span by the short isoform of p53.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Isolation of putative progenitor endothelial cells for angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Circulating endothelial progenitor cells, vascular function, and cardiovascular risk

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Endothelial progenitor cell therapy for the treatment of coronary disease, acute MI, and pulmonary arterial hypertension: current perspectives

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Aging, progenitor cell exhaustion, and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Improvement of endothelial function by systemic transfusion of vascular progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Circulating endothelial progenitor cells and cardiovascular outcomes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere shortening in atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Endothelial progenitor cells in cardiovascular disorders

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Genetic modulation of senescent phenotypes in Homo sapiens

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Mechanisms of cardiovascular disease in accelerated aging syndromes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Histological and ultrastructural features of atherosclerosis in progeria

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

A progeroid syndrome in mice is caused by defects in A-type lamins

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Genomic instability in laminopathy-based premature aging

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Cardiovascular features of the Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Junction of RecQ helicase biochemistry and human disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Telomere dysfunction as a cause of genomic instability in Werner syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Aspirin reduces endothelial cell senescence

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Endocrine regulation of ageing

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO1324

7 January 2021

Identifiers

DOI

10.1038/NCPCARDIO1324

1 reference

4 August 2017

1 reference

PubMed ID

18762784