Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease (Q33971351)

30 July 2017

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title

Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease (English)

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30 July 2017

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T E Golde

1

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30 July 2017

C B Eckman

series ordinal

2

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30 July 2017

S G Younkin

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

1 July 2000

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1502

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30 July 2017

issue

1

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30 July 2017

page(s)

172-187

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Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

30 July 2017

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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7 January 2021

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

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7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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7 January 2021

Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

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7 January 2021

The C-terminus of the beta protein is critical in amyloidogenesis

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7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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7 January 2021

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.

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7 January 2021

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease

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7 January 2021

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

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7 January 2021

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits

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7 January 2021

Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits

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7 January 2021

The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

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7 January 2021

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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7 January 2021

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

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7 January 2021

Neuroimmune mechanisms in Alzheimer disease pathogenesis

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7 January 2021

Complement activation by beta-amyloid in Alzheimer disease

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7 January 2021

Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis

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7 January 2021

The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease

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7 January 2021

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

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7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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7 January 2021

Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains

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7 January 2021

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

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7 January 2021

A detergent-insoluble membrane compartment contains A beta in vivo

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7 January 2021

GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain

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7 January 2021

Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.

1 reference

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7 January 2021

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

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7 January 2021

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

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7 January 2021

The interaction between Alzheimer amyloid beta(1-40) peptide and ganglioside GM1-containing membranes

1 reference

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7 January 2021

Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles

1 reference

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7 January 2021

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

1 reference

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7 January 2021

Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

1 reference

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7 January 2021

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

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7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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7 January 2021

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1 reference

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7 January 2021

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

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7 January 2021

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

1 reference

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7 January 2021

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

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7 January 2021

Distortion of allelic expression of apolipoprotein E in Alzheimer's disease.

1 reference

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7 January 2021

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

1 reference

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7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

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7 January 2021

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

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7 January 2021

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein

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7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

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7 January 2021

Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

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7 January 2021

Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease” 11The names of the Working Group Members and the names of the Working Group Advisory Committee Members are listed in the Appendix A(section VI)

1 reference

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7 January 2021

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2800%2900043-0

7 January 2021

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

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7 January 2021

Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

1 reference

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7 January 2021

High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

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7 January 2021

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

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7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

1 reference

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7 January 2021

No association between the intronic presenilin-1 polymorphism and Alzheimer's disease in clinic and population-based samples

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7 January 2021

Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

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7 January 2021

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

1 reference

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7 January 2021

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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7 January 2021

Alzheimer's soluble amyloid beta is a normal component of human urine

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7 January 2021

10.1016/S0925-4439(00)00043-0

Identifiers

DOI

1 reference

30 July 2017

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