Regulation of thymocyte differentiation: pre-TCR signals and beta-selection (Q34831686)

4 August 2017

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title

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection (English)

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Gene Ontology release 2020-05-02

4 August 2017

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Gene Ontology ID

GO:0043366

pre-T cell receptor complex

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Gene Ontology release 2020-05-02

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Alison M Michie

1

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Juan Carlos Zuniga-Pflucker

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author name string

Juan Carlos Zúñiga-Pflücker

series ordinal

2

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4 August 2017

publication date

1 October 2002

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4 August 2017

published in

Seminars in Immunology

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4 August 2017

volume

14

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4 August 2017

issue

5

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4 August 2017

page(s)

311-323

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Early T lymphocyte progenitors

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Regulation of thymocyte development from immature progenitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Molecular and cellular events in early thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Selection of the T cell repertoire.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Pleiotropic changes controlled by the pre-T-cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Cell migration and the anatomic control of thymocyte precursor differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Analysis and expression of a cloned pre-T cell receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Structure and function of the pre-T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Receptors and signals in early thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Two waves of recombinase gene expression in developing thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Positive selection through a motif in the alphabeta T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Domains of the TCR beta-chain required for early thymocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Different initiation of pre-TCR and gammadeltaTCR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Signal transduction by the TCR for antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Branching out to gain control: how the pre-TCR is linked to multiple functions

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Syk tyrosine kinase required for mouse viability and B-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Essential role of LAT in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Raf regulates positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Membrane lipid microdomains and the role of PKCtheta in T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

T cell activation and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho function

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Different functions of the GTPase Rho in prothymocytes and late pre-T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The GTPase Rho has a critical regulatory role in thymus development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

T cell-specific FADD-deficient mice: FADD is required for early T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Protein tyrosine kinase p56 lck controls allelic exclusion of T-cell receptor β-chain genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The function of E- and Id proteins in lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Early thymocyte development is regulated by modulation of E2A protein activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

LEF1 turns over a new leaf

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Mechanisms of Wnt signaling in development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Signal transmission between the plasma membrane and nucleus of T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Transcription factors in mouse fetal thymus development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900064-7

7 January 2021

10.1016/S1044-5323(02)00064-7

Identifiers

DOI

1 reference

4 August 2017

1 reference