Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes (Q34831727)

4 August 2017

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes (English)

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4 August 2017

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Boris Calderon

3

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Emil R. Unanue

6

object named as

Emil R Unanue

1 reference

4 August 2017

James F Mohan

1

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4 August 2017

Matteo G Levisetti

2

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4 August 2017

Jeremy W Herzog

4

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4 August 2017

Shirley J Petzold

5

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4 August 2017

language of work or name

English

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publication date

28 February 2010

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4 August 2017

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4 August 2017

11

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4 August 2017

4

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4 August 2017

350-354

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Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Insulin as an autoantigen in NOD/human diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Proteomics analysis of insulin secretory granules.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

The NOD mouse: a model of immune dysregulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

APCs present A beta(k)-derived peptides that are autoantigenic to type B T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Distinct recognition by two subsets of T cells of an MHC class II-peptide complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Analysis of the spontaneous T cell response to insulin in NOD mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

The insulin secretory granule

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080751

Quantitative analysis of the T cell repertoire that escapes negative selection

26 October 2018

1 reference

12 December 2020

Culture of dendritic cells from a nonlymphoid organ, the thyroid gland: evidence for TNFalpha-dependent phenotypic changes of thyroid-derived dendritic cells

1 reference

12 December 2020

Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice

1 reference

12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

12 December 2020

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

1 reference

12 December 2020

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1 reference

12 December 2020

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

12 December 2020

HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules

1 reference

12 December 2020

Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion

1 reference

12 December 2020

Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout

1 reference

12 December 2020

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

1 reference

12 December 2020

Unbiased analysis, enrichment and purification of thymic stromal cells

1 reference

12 December 2020

Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.1850

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4 August 2017

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4 August 2017

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