Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action (Q34878868)

5 August 2017

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Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action (English)

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5 August 2017

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Hiroaki Itamochi

1

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5 August 2017

publication date

1 July 2010

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World journal of biological chemistry

5 August 2017

published in

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5 August 2017

volume

1

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5 August 2017

issue

7

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5 August 2017

page(s)

209-220

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A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer

5 August 2017

cites work

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

8 July 2018

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Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours.

8 July 2018

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PARP inhibition: PARP1 and beyond

8 July 2018

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Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2.

8 July 2018

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Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer

8 July 2018

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The rationale for mTOR inhibition in epithelial ovarian cancer

8 July 2018

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Epigenetic therapies for chemoresensitization of epithelial ovarian cancer.

8 July 2018

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Histone deacetylase inhibitors in cancer therapy

8 July 2018

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Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer

8 July 2018

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Aflibercept in epithelial ovarian carcinoma

8 July 2018

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Novel agents on the horizon for cancer therapy

8 July 2018

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Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup

8 July 2018

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Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash

8 July 2018

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Functional significance of VEGFR-2 on ovarian cancer cells

8 July 2018

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Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis

8 July 2018

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Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study

8 July 2018

1 reference

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VEGF-targeted therapy: mechanisms of anti-tumour activity.

8 July 2018

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A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers.

8 July 2018

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8 July 2018

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Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia

8 July 2018

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Proteasome inhibitors in cancer therapy: lessons from the first decade

8 July 2018

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EGFR antagonists in cancer treatment

8 July 2018

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8 July 2018

Epigenetics in cancer

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A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study

8 July 2018

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Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer

8 July 2018

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DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment

8 July 2018

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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

8 July 2018

1 reference

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Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

Defining the role of mTOR in cancer

8 July 2018

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Trastuzumab--mechanism of action and use in clinical practice

8 July 2018

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A proteasome for all occasions

8 July 2018

1 reference

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The epigenomics of cancer

8 July 2018

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Histone deacetylase inhibitors require caspase activity to induce apoptosis in lung and prostate carcinoma cells

8 July 2018

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Epigenetic changes in solid and hematopoietic tumors.

8 July 2018

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AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer

8 July 2018

1 reference

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

8 July 2018

1 reference

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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications

8 July 2018

1 reference

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines

8 July 2018

1 reference

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Gene silencing in cancer in association with promoter hypermethylation

8 July 2018

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Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

8 July 2018

1 reference

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Ovarian cancer: strategies for overcoming resistance to chemotherapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083967

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors

8 July 2018

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

8 July 2018

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Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis

8 July 2018

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A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

8 July 2018

1 reference

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Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells

8 July 2018

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ZD1839 ('Iressa') as an anticancer agent

8 July 2018

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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

8 July 2018

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Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results

8 July 2018

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Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

8 July 2018

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Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer

8 July 2018

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The effects of platelet-derived growth factor and receptor on normal and neoplastic human ovarian surface epithelium

8 July 2018

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The biology of vascular endothelial growth factor

8 July 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

8 July 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

8 July 2018

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

8 July 2018

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Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer

8 July 2018

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Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

8 July 2018

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Tumor angiogenesis: therapeutic implications

8 July 2018

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The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies.

8 July 2018

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Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074).

8 July 2018

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A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group study

26 October 2018

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Imatinib mesylate in combination with docetaxel for the treatment of patients with advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis : a Hoosier Oncology Group trial.

26 October 2018

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The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis

26 October 2018

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Expression of hypoxia-inducible factor 1alpha gene affects the outcome in patients with ovarian cancer.

26 October 2018

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Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia

26 October 2018

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Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer

26 October 2018

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Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer.

26 October 2018

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Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status

26 October 2018

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Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant epithelial ovarian and primary peritoneal cancers.

26 October 2018

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Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study

26 October 2018

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Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study

26 October 2018

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Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosis

26 October 2018

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United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets

26 October 2018

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Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor

26 October 2018

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Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

26 October 2018

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A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer

26 October 2018

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Duration of response to second-line, platinum-based chemotherapy for ovarian cancer: implications for patient management and clinical trial design

9 December 2018

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12 December 2020

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo

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12 December 2020

Tumor angiogenesis and recurrence in stage I non-small cell lung cancer

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12 December 2020

Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival

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12 December 2020

Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma

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12 December 2020

Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer

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12 December 2020

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

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12 December 2020

Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms

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12 December 2020

Identifiers

DOI

10.4331/WJBC.V1.I7.209

1 reference

5 August 2017

1 reference

5 August 2017

1 reference