Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector (Q34892789)

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English	Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector	scientific article

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scholarly article

1 reference

Europe PubMed Central

5 August 2017

Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector (English)

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Europe PubMed Central

5 August 2017

catheterization

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

K Oka

1

1 reference

Europe PubMed Central

5 August 2017

C E Mullins

2

1 reference

Europe PubMed Central

5 August 2017

R S Kushwaha

3

1 reference

Europe PubMed Central

5 August 2017

A M Leen

4

1 reference

Europe PubMed Central

5 August 2017

L Chan

5

1 reference

Europe PubMed Central

5 August 2017

publication date

18 September 2014

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Europe PubMed Central

5 August 2017

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Europe PubMed Central

5 August 2017

22

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Europe PubMed Central

5 August 2017

1

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Europe PubMed Central

5 August 2017

87-95

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Europe PubMed Central

5 August 2017

https://scigraph.springernature.com/pub.10.1038/gt.2014.85

0 references

Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial.

1 reference

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8 July 2018

Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia

1 reference

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8 July 2018

Diagnosis and treatment of familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Potential of proprotein convertase subtilisin/kexin type 9 based therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Gene Therapy Targeting LDL Cholesterol but not HDL Cholesterol Induces Regression of Advanced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Balloon catheter delivery of helper-dependent adenoviral vector results in sustained, therapeutic hFIX expression in rhesus macaques

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

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8 July 2018

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Interleukin-7 induces recruitment of monocytes/macrophages to endothelium

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Recognition of virus infection and innate host responses to viral gene therapy vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

The LDL receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Host immune responses to chronic adenovirus infections in human and nonhuman primates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

PCSK9: a convertase that coordinates LDL catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Frequency, proliferation, and activation of human memory T cells induced by a nonhuman adenovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Improved system for helper-dependent adenoviral vector production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Familial hypercholesterolemia in a rhesus monkey pedigree: molecular basis of low density lipoprotein receptor deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

8 July 2018

Gene therapy for cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised con

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

A dose-titration and comparative study of rosuvastatin and atorvastatin in patients with homozygous familial hypercholesterolaemia

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

RNAi-mediated gene silencing in non-human primates.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals

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https://api.crossref.org/works/10.1038%2FGT.2014.85

21 January 2018

Pseudo-hydrodynamic delivery of helper-dependent adenoviral vectors into non-human primates for liver-directed gene therapy.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

26 October 2018

Genetically determined hypercholesterolemia in a rhesus monkey family due to a deficiency of the LDL receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4289097

26 October 2018

Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo

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https://pubmed.ncbi.nlm.nih.gov/25231173

12 December 2020

based on heuristic

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Relationships of plasma and hepatic variables with rates of plasma low-density lipoprotein apolipoprotein B metabolism in baboons fed low- and high-fat diets

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231173

12 December 2020

based on heuristic

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Characterization of the serum low-density lipoproteins of normal and two rhesus monkeys with spontaneous hyperbeta-lipoproteinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25231173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/GT.2014.85

1 reference

Europe PubMed Central

5 August 2017

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1 reference

Europe PubMed Central

5 August 2017

1 reference

Europe PubMed Central

5 August 2017

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