Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. (Q34940620)

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English	Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.	scientific article

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21 January 2020

Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy (English)

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21 January 2020

phosphorylation

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21 January 2020

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Aslamuzzaman Kazi

1

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21 January 2020

Michelle A Blaskovich

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21 January 2020

Cynthia Bucher

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21 January 2020

Van Thai

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21 January 2020

Stacy Moulder

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21 January 2020

Hairuo Peng

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21 January 2020

Dora Carrico

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21 January 2020

Erin Pusateri

9

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21 January 2020

Warren J Pledger

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21 January 2020

Norbert Berndt

11

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21 January 2020

Andrew Hamilton

12

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21 January 2020

Saïd M Sebti

13

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21 January 2020

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9 February 2009

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21 January 2020

Molecular and Cellular Biology

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21 January 2020

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21 January 2020

8

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21 January 2020

2254-2263

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21 January 2020

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

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Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

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8 July 2018

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

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8 July 2018

Modelling breast cancer: one size does not fit all.

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8 July 2018

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer

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p27Kip1 metabolism: a fascinating labyrinth

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8 July 2018

p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

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8 July 2018

C-terminal phosphorylation controls the stability and function of p27kip1

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8 July 2018

Therapeutic intervention based on protein prenylation and associated modifications

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The ErbB2 signaling network as a target for breast cancer therapy

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The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

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Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

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Rho GTPases: promising cellular targets for novel anticancer drugs

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Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy

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HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

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8 July 2018

RAS and RHO GTPases in G1-phase cell-cycle regulation

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8 July 2018

p27 deregulation in breast cancer: prognostic significance and implications for therapy

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8 July 2018

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8 July 2018

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8 July 2018

Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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8 July 2018

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

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8 July 2018

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

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Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).

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p27 Expression, a cyclin dependent kinase inhibitor in breast carcinoma

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8 July 2018

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine

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Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.

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CDK inhibitors: positive and negative regulators of G1-phase progression

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The geranylgeranyltransferase I inhibitor GGTI-298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin-dependent kinase inhibitors. A potential mechanism for GGTI-298 antitumor activity

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8 July 2018

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

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8 July 2018

p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

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8 July 2018

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

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8 July 2018

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

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8 July 2018

Protein prenylation: molecular mechanisms and functional consequences

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8 July 2018

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8 July 2018

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8 July 2018

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

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8 July 2018

Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton.

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26 October 2018

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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26 October 2018

Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

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12 December 2020

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Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

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12 December 2020

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Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19204084

12 December 2020

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Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

1 reference

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12 December 2020

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Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

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10.1128/MCB.01029-08

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21 January 2020

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21 January 2020

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21 January 2020

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