Therapeutic intervention based on protein prenylation and associated modifications (Q33943379)

30 July 2017

1 reference

title

Therapeutic intervention based on protein prenylation and associated modifications (English)

1 reference

30 July 2017

7

1 reference

30 July 2017

Lucas Brunsveld

2

0 references

author name string

Michael H Gelb

1

1 reference

30 July 2017

Christine A Hrycyna

3

1 reference

30 July 2017

Susan Michaelis

4

1 reference

30 July 2017

Fuyuhiko Tamanoi

5

1 reference

30 July 2017

Wesley C Van Voorhis

6

1 reference

30 July 2017

language of work or name

1 reference

1 October 2006

1 reference

30 July 2017

published in

Nature Chemical Biology

1 reference

30 July 2017

volume

2

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30 July 2017

issue

10

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30 July 2017

page(s)

518-528

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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

30 July 2017

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28 July 2018

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PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility

28 July 2018

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A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity

28 July 2018

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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

28 July 2018

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Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

28 July 2018

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Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

28 July 2018

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Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues

28 July 2018

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Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

28 July 2018

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Lipid posttranslational modifications. Farnesyl transferase inhibitors

28 July 2018

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H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

28 July 2018

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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

28 July 2018

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

28 July 2018

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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

28 July 2018

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

28 July 2018

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Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

28 July 2018

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RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

28 July 2018

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RhoGDI: multiple functions in the regulation of Rho family GTPase activities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Ras signaling from plasma membrane and endomembrane microdomains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Ras plasma membrane signalling platforms

28 July 2018

1 reference

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Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

28 July 2018

1 reference

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The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors

28 July 2018

1 reference

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GDIs: central regulatory molecules in Rho GTPase activation

28 July 2018

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Chemical synthesis of proteins

28 July 2018

1 reference

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Rheb binds and regulates the mTOR kinase

28 July 2018

1 reference

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Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors

28 July 2018

1 reference

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

28 July 2018

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Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

28 July 2018

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Targeting Rab GTPases to distinct membrane compartments

28 July 2018

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On the mechanism of protein palmitoylation

28 July 2018

1 reference

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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Palmitoylation of intracellular signaling proteins: regulation and function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Phase I study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in solid tumors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Methotrexate and Ras methylation: a new trick for an old drug?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Structure of mammalian protein geranylgeranyltransferase type-I

28 July 2018

1 reference

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Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

28 July 2018

1 reference

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New insights into the mechanisms of protein palmitoylation.

28 July 2018

1 reference

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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

28 July 2018

1 reference

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The state of lipid rafts: from model membranes to cells

28 July 2018

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Mechanisms of Ras protein targeting in mammalian cells

28 July 2018

1 reference

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Reaction path of protein farnesyltransferase at atomic resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

28 July 2018

1 reference

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Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.

28 July 2018

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Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

28 July 2018

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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells

28 July 2018

1 reference

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Topological and mutational analysis of Saccharomyces cerevisiae Ste14p, founding member of the isoprenylcysteine carboxyl methyltransferase family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

28 July 2018

1 reference

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Role of rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Genomic analysis of metastasis reveals an essential role for RhoC

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Cloning and characterization of a mammalian prenyl protein-specific protease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Protein prenyltransferases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Frequency of H-ras mutations in human bladder cancer detected by direct sequencing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Human lamin B contains a farnesylated cysteine residue

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Identification of geranylgeranyl-modified proteins in HeLa cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

28 July 2018

1 reference

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A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

28 July 2018

1 reference

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A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

Protein prenyltransferases.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892741

HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

28 July 2018

1 reference

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https://api.crossref.org/works/10.1038%2FNCHEMBIO818

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

21 January 2018

1 reference

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12 December 2020

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12 December 2020

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Substrate specificity of mammalian prenyl protein-specific endoprotease activity

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Identifiers

DOI

10.1038/NCHEMBIO818

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference