A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys (Q34978590)

5 August 2017

title

A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys (English)

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reticulocyte binding protein homologue 5

5 August 2017

main subject

Plasmodium falciparum

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10 September 2018

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14

Alexandra J Spencer

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5 August 2017

Alexander D Douglas

1

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Simon J. Draper

Simon J Draper

24

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Julio Alberto Ventocilla

Julio A Ventocilla

10

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Gavin J. Wright

Gavin J Wright

22

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Kazutoyo Miura

8

Kazutoyo Miura

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21

Carole A Long

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12

Kathryn H Milne

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16

Daniel G W Alanine

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9

Lynn E Lambert

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5

Cécile Crosnier

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2

G Christian Baldeviano

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5 August 2017

4

Luis A Lugo-Roman

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11

Karina P Leiva

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13

Joseph J Illingworth

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Alison V Turner

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7

Ababacar Diouf

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5 August 2017

Carmen M Lucas

3

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5 August 2017

S Josefin Bartholdson

6

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5 August 2017

Kathryn A Hjerrild

15

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5 August 2017

Jeromy T Moorhead

18

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Kimberly A Edgel

19

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5 August 2017

Yimin Wu

20

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5 August 2017

Andrés G Lescano

23

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5 August 2017

publication date

1 January 2015

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5 August 2017

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5 August 2017

volume

17

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5 August 2017

issue

1

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5 August 2017

page(s)

130-139

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Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial

5 August 2017

cites work

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Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection

8 July 2018

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RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing antibodies

8 July 2018

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Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans

8 July 2018

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A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats

8 July 2018

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A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants

8 July 2018

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Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens

8 July 2018

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

8 July 2018

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Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, Peru

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection

8 July 2018

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Global malaria mortality between 1980 and 2010: a systematic analysis

8 July 2018

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The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

8 July 2018

1 reference

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Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus model

8 July 2018

1 reference

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8 July 2018

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Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297294

Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assay

8 July 2018

1 reference

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Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

8 July 2018

1 reference

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Protection induced by Plasmodium falciparum MSP1(42) is strain-specific, antigen and adjuvant dependent, and correlates with antibody responses

8 July 2018

1 reference

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Effective induction of high-titer antibodies by viral vector vaccines

8 July 2018

1 reference

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Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion

8 July 2018

1 reference

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8 July 2018

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Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens

8 July 2018

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Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity

8 July 2018

1 reference

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The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites

8 July 2018

1 reference

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Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria

8 July 2018

1 reference

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In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response

8 July 2018

1 reference

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8 July 2018

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8 July 2018

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8 July 2018

1 reference

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Immunity to non-cerebral severe malaria is acquired after one or two infections

8 July 2018

1 reference

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Selection of different strains of Plasmodium falciparum for testing blood-stage vaccines in Aotus nancymai monkeys

8 July 2018

1 reference

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Malaria vaccine technology roadmap

8 July 2018

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Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines

26 October 2018

1 reference

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Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

26 October 2018

1 reference

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Are trials in New World monkeys on the critical path for blood-stage malaria vaccine development?

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297294

Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4297294

10.1016/J.CHOM.2014.11.017

26 October 2018

Identifiers

DOI

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5 August 2017

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5 August 2017

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