CDKs and CKIs: molecular targets for tissue remodelling (Q34981345)

5 August 2017

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title

CDKs and CKIs: molecular targets for tissue remodelling (English)

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5 August 2017

Elizabeth G Nabel

1

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5 August 2017

publication date

1 August 2002

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Nature Reviews Drug Discovery

5 August 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

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5 August 2017

volume

1

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5 August 2017

issue

8

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5 August 2017

page(s)

587-598

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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

5 August 2017

cites work

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

31 March 2020

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WAF1, a potential mediator of p53 tumor suppression

31 March 2020

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p21 is a universal inhibitor of cyclin kinases

31 March 2020

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

31 March 2020

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

31 March 2020

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

31 March 2020

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p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

31 March 2020

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Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution

31 March 2020

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p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

31 March 2020

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

31 March 2020

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Cyclin-binding motifs are essential for the function of p21CIP1

31 March 2020

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A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

31 March 2020

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Analysis of wild-type and mutant p21WAF-1 gene activities

31 March 2020

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

31 March 2020

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

31 March 2020

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

31 March 2020

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

31 March 2020

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31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

31 March 2020

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Expression of cyclin-dependent kinase inhibitors in vascular disease

31 March 2020

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Cyclin E-CDK2 is a regulator of p27Kip1.

31 March 2020

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

31 March 2020

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

31 March 2020

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Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

31 March 2020

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Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter

31 March 2020

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

31 March 2020

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Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms

31 March 2020

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Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

31 March 2020

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Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

31 March 2020

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Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation

31 March 2020

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

31 March 2020

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

31 March 2020

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

31 March 2020

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

31 March 2020

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

31 March 2020

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

31 March 2020

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

31 March 2020

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

31 March 2020

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

31 March 2020

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

31 March 2020

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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

31 March 2020

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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

31 March 2020

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Radiation-induced cell cycle arrest compromised by p21 deficiency

31 March 2020

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

31 March 2020

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

31 March 2020

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

31 March 2020

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Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

31 March 2020

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p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

31 March 2020

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Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes

31 March 2020

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Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

31 March 2020

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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

31 March 2020

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Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

31 March 2020

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Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

31 March 2020

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Cell proliferation in human coronary arteries

31 March 2020

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Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors

31 March 2020

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Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation.

31 March 2020

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Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury

31 March 2020

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Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty

31 March 2020

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ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines)—executive summary21When citing this document, the American College of Cardiology and the American Heart Association would appreciate the following cita

31 March 2020

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Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty

31 March 2020

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

31 March 2020

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

31 March 2020

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Cellular functions of immunophilins

31 March 2020

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Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

31 March 2020

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Rapamycin inhibits vascular smooth muscle cell migration

31 March 2020

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

31 March 2020

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Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle

31 March 2020

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Rapamycin resistance tied to defective regulation of p27Kip1.

31 March 2020

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Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration

31 March 2020

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Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study

31 March 2020

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Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up

31 March 2020

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A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization

31 March 2020

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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

31 March 2020

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Taxol stabilizes microtubules in mouse fibroblast cells

31 March 2020

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31 March 2020

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Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat

31 March 2020

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Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis

31 March 2020

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Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

31 March 2020

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A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer

31 March 2020

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Hematopoietic stem cell quiescence maintained by p21cip1/waf1

31 March 2020

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Stem cell repopulation efficiency but not pool size is governed by p27(kip1).

31 March 2020

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The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

31 March 2020

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31 March 2020

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p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

31 March 2020

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Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2

31 March 2020

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Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

31 March 2020

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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

31 March 2020

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p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line.

31 March 2020

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The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy

31 March 2020

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Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

31 March 2020

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p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

31 March 2020

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31 March 2020

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

31 March 2020

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p53, the cellular gatekeeper for growth and division

31 March 2020

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The complexity of p53 modulation: emerging patterns from divergent signals

31 March 2020

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The retinoblastoma protein and cell cycle control

31 March 2020

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The INK4a/ARF network in tumour suppression

31 March 2020

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The cellular response to p53: the decision between life and death

31 March 2020

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Mechanisms of p53-mediated apoptosis

31 March 2020

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

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31 March 2020

Gene therapy of cancer

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Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

31 March 2020

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Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics

31 March 2020

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

31 March 2020

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Small molecule modulators of cyclin-dependent kinases for cancer therapy

31 March 2020

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Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

31 March 2020

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Identification of E2F-1/Cyclin A antagonists.

31 March 2020

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An artificial cell-cycle inhibitor isolated from a combinatorial library

31 March 2020

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Combinatorial protein reagents to manipulate protein function.

31 March 2020

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Cyclin E in human cancers.

31 March 2020

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

31 March 2020

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

31 March 2020

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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

31 March 2020

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Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells

31 March 2020

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The murine gene p27Kip1 is haplo-insufficient for tumour suppression

31 March 2020

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Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

31 March 2020

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Cell cycle and cell migration: new pieces to the puzzle

31 March 2020

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Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD869

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5 August 2017

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