DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype (Q34984492)

5 August 2017

title

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype (English)

1 reference

5 August 2017

1 reference

Mauro Congia

4

0 references

Sascha Al Dahouk

Sascha Al Dahouk

11

0 references

Thomas Kamradt

Thomas Kamradt

12

0 references

Constantin Polychronakos

Constantin Polychronakos

17

0 references

Markus Maeurer

Markus J Maeurer

13

0 references

Gerald T Nepom

18

Gerald T Nepom

1 reference

5 August 2017

9

Jan W Drijfhout

1 reference

5 August 2017

author name string

Ivana Durinovic-Belló

1

1 reference

5 August 2017

Silke Rosinger

2

1 reference

5 August 2017

Jennifer A Olson

3

1 reference

5 August 2017

Regina C Ahmad

5

1 reference

5 August 2017

Mathias Rickert

6

1 reference

5 August 2017

Johannes Hampl

7

1 reference

5 August 2017

Hubert Kalbacher

8

1 reference

5 August 2017

Elizabeth D Mellins

10

1 reference

5 August 2017

Carol Nhan

14

1 reference

5 August 2017

Bart O Roep

15

1 reference

5 August 2017

Bernhard O Boehm

16

1 reference

5 August 2017

Wolfram Karges

19

1 reference

5 August 2017

Hugh O McDevitt

20

1 reference

5 August 2017

Grete Sønderstrup

21

1 reference

5 August 2017

language of work or name

English

0 references

publication date

25 July 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

1 reference

5 August 2017

volume

103

1 reference

5 August 2017

issue

31

1 reference

5 August 2017

page(s)

11683-11688

1 reference

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

An integrated view of suppressor T cell subsets in immunoregulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Positive and negative selection of T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Identification of autoantigen epitopes in MHC class II transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Modulation of the immunogenicity of antigenic determinants by their flanking residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Recognition of core and flanking amino acids of MHC class II-bound peptides by the T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Class III alleles at the insulin VNTR polymorphism are associated with regulatory T-cell responses to proinsulin epitopes in HLA-DR4, DQ8 individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1544230

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603682103

Cytokines elicited by T cell epitopes from a synovial autoantigen: altered peptide ligands can reduce interferon-gamma and interleukin-10 production

21 January 2018

1 reference

12 December 2020

Relationship between T and B cell responses to proinsulin in human type 1 diabetes

1 reference

12 December 2020

Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes

1 reference

12 December 2020

Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects

1 reference

12 December 2020

Cellular immune responses against proinsulin: no evidence for enhanced reactivity in individuals with IDDM

1 reference

12 December 2020

Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with Type I diabetes: the German BABYDIAB study

1 reference

12 December 2020

Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0603682103

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference