The liver X receptor gene team: potential new players in atherosclerosis (Q34986358)

5 August 2017

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title

The liver X receptor gene team: potential new players in atherosclerosis (English)

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5 August 2017

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Joyce J Repa

1

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5 August 2017

David J Mangelsdorf

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

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5 August 2017

8

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5 August 2017

1243-1248

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5 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nm1102-1243

5 August 2017

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LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing

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7 January 2021

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

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7 January 2021

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

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7 January 2021

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

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7 January 2021

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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7 January 2021

Role of LXRs in control of lipogenesis

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7 January 2021

A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux

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7 January 2021

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

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7 January 2021

Mouse models of atherosclerosis

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7 January 2021

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

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7 January 2021

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

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7 January 2021

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

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7 January 2021

Identification of macrophage liver X receptors as inhibitors of atherosclerosis

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7 January 2021

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

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7 January 2021

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

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7 January 2021

Autoregulation of the human liver X receptor alpha promoter

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7 January 2021

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

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7 January 2021

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

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7 January 2021

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

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7 January 2021

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

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7 January 2021

Homozygous Tangier disease and cardiovascular disease

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7 January 2021

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

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7 January 2021

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

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7 January 2021

Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice.

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7 January 2021

Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages

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7 January 2021

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

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7 January 2021

Increased ABCA1 activity protects against atherosclerosis.

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7 January 2021

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

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7 January 2021

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

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7 January 2021

Apolipoprotein E and atherosclerosis

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7 January 2021

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

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7 January 2021

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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7 January 2021

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

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7 January 2021

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

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7 January 2021

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Adenovirus-mediated gene transfer of human lipoprotein lipase ameliorates the hyperlipidemias associated with apolipoprotein E and LDL receptor deficiencies in mice

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7 January 2021

Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice

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7 January 2021

Phospholipid transfer protein is regulated by liver X receptors in vivo

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7 January 2021

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

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7 January 2021

Phospholipid transfer protein

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation

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7 January 2021

Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice.

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7 January 2021

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression.

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Control of cholesterol turnover in the mouse

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Genetic basis of sitosterolemia

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism.

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

The Molecular Pharmacology of SERMs

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https://api.crossref.org/works/10.1038%2FNM1102-1243

7 January 2021

Identifiers

DOI

10.1038/NM1102-1243

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Dimensions Publication ID

5 August 2017

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