Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties (Q34989248)

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English	Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties	scientific article

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Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties (English)

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negative regulation of biological process

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CCAAT-enhancer-binding proteins

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22 December 2019

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tumor suppressor gene

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24 December 2020

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Christian Bronner

7

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Mahmoud Alhosin

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Tanveer Sharif

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Marc Mousli

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Nelly Etienne-Selloum

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Guy Fuhrmann

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Valérie B Schini-Kerth

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Journal of Experimental & Clinical Cancer Research

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on focus list of Wikimedia project

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https://scigraph.springernature.com/pub.10.1186/1756-9966-30-41

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UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.

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Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

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UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis

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Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

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Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.

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Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

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Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis.

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UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications

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Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

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Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

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The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

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Cancer epigenetics comes of age

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Nutrition and colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096999

8 July 2018

DNA Methylation and Gene Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096999

8 July 2018

X-chromosome inactivation and cell memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096999

8 July 2018

Increased expression of histone deacetylase 2 is found in human gastric cancer.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Modulation of endothelial nitric oxide by plant-derived products.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.

1 reference

https://api.crossref.org/works/10.1186%2F1756-9966-30-41

21 January 2018

Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096999

26 October 2018

The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3096999

26 October 2018

Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Promoter hypermethylation and CpG island methylator phenotype in colorectal carcinogenesis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fundamental role of epigenetic events in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21496237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1756-9966-30-41

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496237%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Dimensions Publication ID

0 references

Internet Archive ID

pubmed-PMC3096999

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496237%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21496237%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

ResearchGate publication ID

0 references

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