Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts. (Q34995163)

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English	Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts.	scientific article

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28 February 2020

Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts (English)

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28 February 2020

Jaclyn N Taroni

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28 February 2020

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Michael E Johnson

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28 February 2020

J Matthew Mahoney

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28 February 2020

Jennifer L Sargent

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28 February 2020

Eleni Marmarelis

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28 February 2020

Ming-Ru Wu

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28 February 2020

John Varga

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28 February 2020

Monique E Hinchcliff

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28 February 2020

Michael L Whitfield

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21 January 2015

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28 February 2020

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28 February 2020

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28 February 2020

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28 February 2020

e0114017

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28 February 2020

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Creative Commons Attribution 4.0 International

21 January 2015

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0 references

Innate immunity in systemic sclerosis pathogenesis

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Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

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8 July 2018

The role of type 1 interferon in systemic sclerosis

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8 July 2018

Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis

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8 July 2018

Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis

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8 July 2018

Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities

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8 July 2018

Tumor necrosis factor

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8 July 2018

Janus-like effects of type I interferon in autoimmune diseases

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8 July 2018

IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?

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8 July 2018

Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies.

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8 July 2018

Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets

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8 July 2018

Immune regulation by sphingosine 1-phosphate and its receptors

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8 July 2018

Interferons in autoimmune and inflammatory diseases: regulation and roles

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8 July 2018

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.

1 reference

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8 July 2018

Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease

1 reference

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8 July 2018

PDGFRβ signaling regulates mural cell plasticity and inhibits fat development.

1 reference

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8 July 2018

Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6

1 reference

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8 July 2018

Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus

1 reference

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8 July 2018

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis

1 reference

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8 July 2018

Th17 cells in inflammation

1 reference

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8 July 2018

Recent advances in pulmonary fibrosis: implications for scleroderma

1 reference

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8 July 2018

Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Systemic sclerosis and lupus: points in an interferon-mediated continuum

1 reference

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8 July 2018

A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity

1 reference

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8 July 2018

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

1 reference

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8 July 2018

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

1 reference

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8 July 2018

Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis

1 reference

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8 July 2018

Molecular framework for response to imatinib mesylate in systemic sclerosis.

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8 July 2018

Role of PDGF in fibrotic diseases and systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Molecular subsets in the gene expression signatures of scleroderma skin

1 reference

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8 July 2018

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8 July 2018

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1 reference

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8 July 2018

Java Treeview--extensible visualization of microarray data

1 reference

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8 July 2018

Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Cytokine regulation of pulmonary fibrosis in scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Systemic and cell type-specific gene expression patterns in scleroderma skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

1 reference

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8 July 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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8 July 2018

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

1 reference

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8 July 2018

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

1 reference

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8 July 2018

Molecular portraits of human breast tumours

1 reference

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8 July 2018

Immunomodulation and therapeutic effects of the oral use of interferon-alpha: mechanism of action

1 reference

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8 July 2018

Cluster analysis and display of genome-wide expression patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4301872

8 July 2018

Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0114017

21 January 2018

Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0114017

21 January 2018

Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0114017

21 January 2018

Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0114017

21 January 2018

Skin distribution and differential expression of transforming growth factor beta 1 and beta 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon alfa and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistological demonstration of transforming growth factor-beta isoforms in the skin of patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th17 peripheral cells are increased in diffuse cutaneous systemic sclerosis compared with limited illness: a cross-sectional study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scleroderma (systemic sclerosis): classification, subsets and pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of soluble CD163 in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Plasma Levels of Platelet-Derived Growth Factor Activity in Patients with Progressive Systemic Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine concentrations in bronchoalveolar lavage fluid of patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible implication of the effector CD4+ T-cell subpopulation TH17 in the pathogenesis of systemic scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25607805

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0114017

1 reference

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28 February 2020

2015PLoSO..1014017J

0 references

1 reference

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28 February 2020

1 reference

Europe PubMed Central

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28 February 2020

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