Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma (Q37712557)

22 August 2017

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma (English)

1 reference

22 August 2017

Elizabeth E Gerber

1

1 reference

22 August 2017

Elena M Gallo

2

1 reference

22 August 2017

Stefani C Fontana

3

1 reference

22 August 2017

Elaine C Davis

4

1 reference

22 August 2017

Fredrick M Wigley

5

1 reference

22 August 2017

David L Huso

6

1 reference

22 August 2017

Harry C Dietz

7

1 reference

22 August 2017

language of work or name

English

0 references

publication date

9 October 2013

1 reference

22 August 2017

1 reference

22 August 2017

503

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22 August 2017

7474

1 reference

22 August 2017

126-130

1 reference

Matrix-dependent perturbation of TGFβ signaling and disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Lessons on the pathogenesis of aneurysm from heritable conditions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Type I interferons: crucial participants in disease amplification in autoimmunity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Transforming growth factor beta as a therapeutic target in systemic sclerosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Functions of TGF-β-exposed plasmacytoid dendritic cells.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Autoantibodies in scleroderma and tightskin mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Plasmacytoid dendritic cells regulate autoreactive B cell activation via soluble factors and in a cell-to-cell contact manner

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3992987

Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

1 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Remodeling of elastic fiber components in scleroderma skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Plasmacytoid dendritic cells in tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

A Critical Role for Prostaglandin E2 in Podosome Dissolution and Induction of High-Speed Migration during Dendritic Cell Maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24107997

12 December 2020

inferred from PubMed ID database lookup

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24107997

12 December 2020

inferred from PubMed ID database lookup

Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

7 January 2021

inferred from DOI database lookup

Derivation of primary mouse embryonic fibroblast (PMEF) cultures

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12614

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE12614

1 reference

Dimensions Publication ID

22 August 2017

0 references

1 reference

22 August 2017

PubMed publication ID

24107997

1 reference