Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (Q34996827)

5 August 2017

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title

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (English)

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5 August 2017

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2

Judith Klumperman

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author name string

Paul Saftig

series ordinal

1

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PubMed ID

19672277

5 August 2017

language of work or name

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12 August 2009

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Nature Reviews Molecular Cell Biology

5 August 2017

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5 August 2017

10

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5 August 2017

623-635

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5 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrm2745

5 August 2017

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cites work

Insights into the biogenesis of lysosome-related organelles from the study of the Hermansky-Pudlak syndrome

1 reference

The building BLOC(k)s of lysosomes and related organelles

31 March 2020

1 reference

Cathepsins: key modulators of cell death and inflammatory responses

31 March 2020

1 reference

Proteomics of the lysosome

31 March 2020

1 reference

Integral and associated lysosomal membrane proteins

31 March 2020

1 reference

The integral membrane of lysosomes: its proteins and their roles in disease

31 March 2020

1 reference

At the acidic edge: emerging functions for lysosomal membrane proteins

31 March 2020

1 reference

The biogenesis of lysosomes

31 March 2020

1 reference

Molecular and cellular basis of lysosomal transmembrane protein dysfunction

31 March 2020

1 reference

Endosomes: multipurpose designs for integrating housekeeping and specialized tasks

31 March 2020

1 reference

Late endosomes derive from early endosomes by maturation

31 March 2020

1 reference

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes

31 March 2020

1 reference

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes

31 March 2020

1 reference

Maturation models for endosome and lysosome biogenesis

31 March 2020

1 reference

Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells.

31 March 2020

1 reference

The biogenesis of multivesicular endosomes

31 March 2020

1 reference

Lysosomes: fusion and function

31 March 2020

1 reference

SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors

31 March 2020

1 reference

Differences in the endosomal distributions of the two mannose 6-phosphate receptors

31 March 2020

1 reference

Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells

31 March 2020

1 reference

Tubular early endosomal networks in AtT20 and other cells

31 March 2020

1 reference

A novel class of clathrin-coated vesicles budding from endosomes

31 March 2020

1 reference

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins

31 March 2020

1 reference

Imaging and imagination: understanding the endo-lysosomal system

31 March 2020

1 reference

Retrograde transport from endosomes to the trans-Golgi network

31 March 2020

1 reference

Relations between plasma membrane and lysosomal membrane. 1. Fate of covalently labelled plasma membrane protein

31 March 2020

1 reference

Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway

31 March 2020

1 reference

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport

31 March 2020

1 reference

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

31 March 2020

1 reference

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

31 March 2020

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Recycle your receptors with retromer

31 March 2020

1 reference

31 March 2020

1 reference

Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors

31 March 2020

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Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

31 March 2020

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Rab conversion as a mechanism of progression from early to late endosomes

31 March 2020

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Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

31 March 2020

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Tracing the retrograde route in protein trafficking.

31 March 2020

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mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

31 March 2020

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Association of the AP-3 adaptor complex with clathrin

31 March 2020

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Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor

31 March 2020

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Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes

31 March 2020

1 reference

The molecular machinery for the biogenesis of lysosome-related organelles: lessons from Hermansky-Pudlak syndrome

31 March 2020

1 reference

31 March 2020

1 reference

ESCRTing proteins in the endocytic pathway

31 March 2020

1 reference

Endosome protein sorting: motifs and machinery

31 March 2020

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

31 March 2020

1 reference

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

31 March 2020

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ESCRTing membrane deformation

31 March 2020

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Functional reconstitution of ESCRT-III assembly and disassembly

31 March 2020

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Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

31 March 2020

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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

31 March 2020

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Hrs recruits clathrin to early endosomes

31 March 2020

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The UIM domain of Hrs couples receptor sorting to vesicle formation

31 March 2020

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Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes

31 March 2020

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Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains

31 March 2020

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Endosomal compartmentalization in three dimensions: Implications for membrane fusion

31 March 2020

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Human VPS34 is required for internal vesicle formation within multivesicular endosomes

31 March 2020

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Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

31 March 2020

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Trafficking and function of the tetraspanin CD63.

31 March 2020

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Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

31 March 2020

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Ceramide triggers budding of exosome vesicles into multivesicular endosomes

31 March 2020

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Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

31 March 2020

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Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination

31 March 2020

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Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.

31 March 2020

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Multivesicular bodies: co-ordinated progression to maturity

31 March 2020

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Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function

31 March 2020

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A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology

31 March 2020

2 references

31 March 2020

12 December 2020

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles

1 reference

The mannose 6-phosphate receptor and the biogenesis of lysosomes

31 March 2020

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Sorting of lysosomal proteins

31 March 2020

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A novel Rab9 effector required for endosome-to-TGN transport

31 March 2020

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Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins

31 March 2020

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PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

31 March 2020

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Clathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes

31 March 2020

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Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes

31 March 2020

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TIP47 functions in the biogenesis of lipid droplets

31 March 2020

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TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking

31 March 2020

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Homotypic lysosome fusion in macrophages: analysis using an in vitro assay

31 March 2020

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Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent

31 March 2020

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The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins

31 March 2020

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A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi

31 March 2020

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GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex

31 March 2020

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A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome

31 March 2020

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Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network

31 March 2020

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Sorting of mannose 6-phosphate receptors mediated by the GGAs

31 March 2020

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Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network

31 March 2020

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Possible pathways for lysosomal enzyme delivery

31 March 2020

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Ultrastructure of long-range transport carriers moving from the trans Golgi network to peripheral endosomes.

31 March 2020

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Coat proteins: shaping membrane transport

31 March 2020

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Enzymatic phosphorylation of lysosomal enzymes in the presence of UDP-N-acetylglucosamine. Absence of the activity in I-cell fibroblasts

31 March 2020

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Deficiency of UDP-N-acetylglucosamine: Lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients

31 March 2020

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Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

31 March 2020

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Properties of N-acetylglucosamine 1-phosphotransferase from human lymphoblasts

31 March 2020

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Is there a mechanism for introducing acid hydrolases into liver lysosomes that is independent of mannose 6-phosphate recognition? Evidence from I-cell disease

31 March 2020

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Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase exhibit growth retardation, retinal degeneration, and secretory cell lesions

31 March 2020

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From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor

31 March 2020

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Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.

31 March 2020

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The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

31 March 2020

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The genes for the human VPS10 domain-containing receptors are large and contain many small exons

31 March 2020

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VPS10P-domain receptors - regulators of neuronal viability and function.

31 March 2020

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The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor

31 March 2020

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Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

31 March 2020

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The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

31 March 2020

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Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).

31 March 2020

1 reference

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

31 March 2020

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The lysomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

31 March 2020

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Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval

31 March 2020

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Sortilin mediates the lysosomal targeting of cathepsins D and H

31 March 2020

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Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

31 March 2020

1 reference

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

31 March 2020

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LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice

31 March 2020

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X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

31 March 2020

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The NH(2)-terminal transmembrane and lumenal domains of LGP85 are needed for the formation of enlarged endosomes/lysosomes.

31 March 2020

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Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.

31 March 2020

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Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis

31 March 2020

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A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome

31 March 2020

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Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

31 March 2020

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Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins

31 March 2020

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The lysosomal membrane glycoprotein lamp-1 is transported to lysosomes by two alternative pathways

31 March 2020

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Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants

31 March 2020

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Transport of the lysosomal membrane glycoprotein lgp120 (lgp-A) to lysosomes does not require appearance on the plasma membrane

31 March 2020

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Membrane dynamics and the biogenesis of lysosomes

31 March 2020

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Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes

31 March 2020

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

31 March 2020

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Intracellular trafficking of lysosomal membrane proteins.

31 March 2020

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Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

31 March 2020

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Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network.

31 March 2020

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Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments

31 March 2020

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The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts

31 March 2020

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RETRACTED: VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification

31 March 2020

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Cholesterol sensing, trafficking, and esterification.

31 March 2020

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SNAREs--engines for membrane fusion

31 March 2020

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A dual mechanism controlling the localization and function of exocytic v-SNAREs

31 March 2020

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Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb

31 March 2020

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A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis

31 March 2020

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Different steady state subcellular distributions of the three splice variants of lysosome-associated membrane protein LAMP-2 are determined largely by the COOH-terminal amino acid residue

31 March 2020

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Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium

31 March 2020

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Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

31 March 2020

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LAMP proteins are required for fusion of lysosomes with phagosomes

31 March 2020

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Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

31 March 2020

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Neuraminidase 1 is a negative regulator of lysosomal exocytosis

31 March 2020

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Two-way traffic on the road to plasma membrane repair

31 March 2020

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Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis

31 March 2020

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A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons

31 March 2020

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TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages

31 March 2020

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A process for controlling intracellular bacterial infections induced by membrane injury

31 March 2020

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Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells

31 March 2020

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1. Membrane origin for autophagy

31 March 2020

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

31 March 2020

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Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).

31 March 2020

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Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts

31 March 2020

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Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.

31 March 2020

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Role for Rab7 in maturation of late autophagic vacuoles

31 March 2020

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Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.

31 March 2020

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A receptor for the selective uptake and degradation of proteins by lysosomes

31 March 2020

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Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens

31 March 2020

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

31 March 2020

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

31 March 2020

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Exiting the Golgi complex

31 March 2020

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deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster

31 March 2020

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The interactomics of sortilin: an ancient lysosomal receptor evolving new functions

31 March 2020

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12 December 2020

Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts

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12 December 2020

Alternative mechanisms for trafficking of lysosomal enzymes in mannose 6-phosphate receptor-deficient mice are cell type-specific.

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12 December 2020

Lysosomal enzymes and their receptors

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12 December 2020

Lysosome-related organelles

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12 December 2020

MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways.

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12 December 2020

Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials

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12 December 2020

Coiled-coil interactions are required for post-Golgi R-SNARE trafficking

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12 December 2020

Multivesicular bodies in HEp-2 cells are maturing endosomes

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12 December 2020

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles

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12 December 2020

Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking

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12 December 2020

Identifiers

DOI

10.1038/NRM2745

1 reference

PubMed ID

19672277

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

19672277