Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation (Q35001642)

5 August 2017

title

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation (English)

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5 August 2017

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15

David T Scadden

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1

Andrea U Steinbicker

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author name string

Chetana Sachidanandan

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Ashley J Vonner

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Rushdia Z Yusuf

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Donna Y Deng

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Carol S Lai

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Kristen M Rauwerdink

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Julia C Winn

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Borja Saez

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Colleen M Cook

10

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Brian A Szekely

11

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Cindy N Roy

12

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Jasbir S Seehra

13

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Gregory D Cuny

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Randall T Peterson

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Kenneth D Bloch

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Paul B Yu

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language of work or name

English

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publication date

10 March 2011

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5 August 2017

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5 August 2017

volume

117

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issue

18

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page(s)

4915-4923

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Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors

5 August 2017

cites work

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Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

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A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

8 July 2018

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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

8 July 2018

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The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters

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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

8 July 2018

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Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

8 July 2018

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Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat

8 July 2018

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Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

8 July 2018

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STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

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Interleukin-6 induces hepcidin expression through STAT3

8 July 2018

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

8 July 2018

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

8 July 2018

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

8 July 2018

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Ferroportin1 is required for normal iron cycling in zebrafish

8 July 2018

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Anemia of chronic disease.

8 July 2018

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

8 July 2018

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The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes

8 July 2018

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

8 July 2018

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Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

8 July 2018

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

8 July 2018

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8 July 2018

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8 July 2018

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

8 July 2018

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8 July 2018

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IL-6 up-regulates mcl-1 in human myeloma cells through JAK / STAT rather than ras / MAP kinase pathway

8 July 2018

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Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins

8 July 2018

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8 July 2018

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

8 July 2018

1 reference

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Involvement of hepcidin in the anemia of multiple myeloma

26 October 2018

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Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study.

26 October 2018

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Cooperativity of binding epitopes and receptor chains in the BMP/TGFbeta superfamily

26 October 2018

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Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction

26 October 2018

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12 December 2020

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

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12 December 2020

Haemoglobin targets: we were wrong, time to move on

1 reference

12 December 2020

Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure

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12 December 2020

New and old players in the hepcidin pathway

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12 December 2020

STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo

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12 December 2020

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

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12 December 2020

10.1182/BLOOD-2010-10-313064

Identifiers

DOI

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5 August 2017

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5 August 2017

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