Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators. (Q35006483)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

review article

1 reference

title

Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

0 references

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Bruno Vincent

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

publication date

1 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

published in

Trends in Neurosciences

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

616-620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

Prion protein amyloidosis

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

1 reference

7 January 2021

Prion protein and the transmissible spongiform encephalopathy diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Prions: health scare and biological challenge.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Heterogeneity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Genetic and molecular advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Genetic dissection of Alzheimer disease, a heterogeneous disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

The shifting biology of prions

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Prion diseases: what is the neurotoxic molecule?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Prion and prejudice: normal protein and the synapse

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Role of the beta-amyloid protein in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Molecular biology and pathogenesis of prion diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Neurotoxicity of a prion protein fragment.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Prion protein peptides: optimal toxicity and peptide blockade of toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

In vivo cytotoxicity of the prion protein fragment 106-126

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Caspase-3 activation by beta-amyloid and prion protein peptides is independent from their neurotoxic effect

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Activation of caspase-8 in the Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Prion protein fragment PrP-(106-126) induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

PrP and beta-amyloid fragments activate different neurotoxic mechanisms in cultured mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Secretases as therapeutic targets for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Amyloid metabolism and secretases in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Cellular and molecular basis of beta-amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Role for ADAM-family proteinases as membrane protein secretases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Truncated forms of the human prion protein in normal brain and in prion diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Phorbol ester-regulated cleavage of normal prion protein in HEK293 human cells and murine neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Mice devoid of PrP are resistant to scrapie

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Normal host prion protein necessary for scrapie-induced neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2802%2902263-4

7 January 2021

10.1016/S0166-2236(02)02263-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446128%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference