Cycling at the interface between neurodevelopment and neurodegeneration (Q35023927)

5 August 2017

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title

Cycling at the interface between neurodevelopment and neurodegeneration (English)

1 reference

5 August 2017

Nguyen MD

1

1 reference

PubMed ID

12478466

5 August 2017

Mushynski WE

series ordinal

2

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PubMed ID

12478466

5 August 2017

Julien JP

series ordinal

3

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5 August 2017

1 December 2002

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Cell Death & Differentiation

5 August 2017

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5 August 2017

9

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5 August 2017

12

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5 August 2017

1294-1306

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401108

5 August 2017

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cyclin-dependent kinases: engines, clocks, and microprocessors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Role of cyclins in neuronal differentiation of immortalized hippocampal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cell cycle regulation of a Xenopus Wee1-like kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The cdc25 protein contains an intrinsic phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Structure and regulation of the CDK5-p25(nck5a) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Structural principles in cell-cycle control: beyond the CDKs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Mutational analysis of the Cy motif from p21 reveals sequence degeneracy and specificity for different cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Region-specific expression of cell cycle inhibitors in the adult brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of expression and activity of distinct pRB, E2F, D-type cyclin, and CKI family members during terminal differentiation of P19 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Neuronal apoptosis at the G1/S cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cyclin-dependent kinases as a therapeutic target for stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of neuronal survival and death by E2F-dependent gene repression and derepression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Altered distribution of cell cycle transcriptional regulators during Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Innate immunity: the missing link in neuroprotection and neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

A novel disruption of cortical development in p35(-/-) mice distinct from reeler.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

LIS1. let's interact sometimes... (part 1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Transcriptional regulation of cortical neuron migration by POU domain factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Role of the reelin signaling pathway in central nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Callosal axon guidance defects in p35(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Neuroscience. A kinase to dampen the effects of cocaine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The neurobiology of slow synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase. I. Identification of the kinase and its role in the turnoff of phosphodiesterase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Regulation of NMDA receptors by cyclin-dependent kinase-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Alterations in cyclin-dependent protein kinase 5 (CDK5) protein levels, activity and immunocytochemistry in canine motor neuron disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Detyrosination of tubulin regulates the interaction of intermediate filaments with microtubules in vivo via a kinesin-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The Sp-family of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

RB and Cdc2 expression in brain: correlations with 3H-thymidine incorporation and neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Neurofilaments in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Neocortical cell migration: GABAergic neurons and cells in layers I and VI move in a cyclin-dependent kinase 5-independent manner.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Neuronal cyclin-dependent kinase 5 activity is critical for survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Cyclin-dependent kinase 5 is required for associative learning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401108

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401108

1 reference

5 August 2017

1 reference

PubMed ID

12478466