Profound methyl effects in drug discovery and a call for new C-H methylation reactions (Q35024529)

5 August 2017

title

Profound methyl effects in drug discovery and a call for new C-H methylation reactions (English)

1 reference

5 August 2017

1 reference

Heike Schönherr

1

1 reference

5 August 2017

Tim Cernak

series ordinal

2

1 reference

5 August 2017

language of work or name

English

0 references

publication date

22 October 2013

1 reference

Angewandte Chemie International Edition

5 August 2017

published in

0 references

volume

52

1 reference

5 August 2017

issue

47

1 reference

5 August 2017

page(s)

12256-12267

1 reference

The methylation effect in medicinal chemistry.

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Mu opioid receptor antagonists: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

21 January 2018

Hydrophobic interactions

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A View of the Hydrophobic Effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Comparative QSAR: Toward a Deeper Understanding of Chemicobiological Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Functional group contributions to drug-receptor interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Methyl effects on protein-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Torsion angle preferences in druglike chemical space: a comprehensive guide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid .kappa. agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A medicinal chemist's guide to molecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

The identification of novel orally active mGluR5 antagonist GSK2210875.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Catalysis for fluorination and trifluoromethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A new reagent for direct difluoromethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Practical and innate carbon-hydrogen functionalization of heterocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Copper-mediated difluoromethylation of aryl and vinyl iodides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Copper-mediated difluoromethylation of (hetero)aryl iodides and β-styryl halides with tributyl(difluoromethyl)stannane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Efficient Difluoromethylation of sp(3) Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A two-step, formal [4 + 2] approach toward piperidin-4-ones via Au catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Directed ortho metalation. Tertiary amide and O-carbamate directors in synthetic strategies for polysubstituted aromatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Beyond thermodynamic acidity: a perspective on the complex-induced proximity effect (CIPE) in deprotonation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Palladium-catalyzed alkylation of aryl C-H bonds with sp3 organotin reagents using benzoquinone as a crucial promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Palladium-catalyzed methylation of aryl C-H bond by using peroxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Mild palladium-catalyzed C-H alkylation using potassium alkyltrifluoroborates in combination with MnF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Rhodium(I)-catalyzed redox-economic cross-coupling of carboxylic acids with arenes directed by N-containing groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Innate and Guided C–H Functionalization Logic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Regioselective, Diastereoselective, and Enantioselective Lithiation−Substitution Sequences: Reaction Pathways and Synthetic Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Asymmetric deprotonation of N-boc piperidine: react IR monitoring and mechanistic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Pd(II)-catalyzed cross-coupling of sp3 C-H Bonds with sp2 and sp3 boronic acids using air as the oxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Guiding principles for site selective and stereoselective intermolecular C-H functionalization by donor/acceptor rhodium carbenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Mechanism of C[bond]H bond activation/C[bond]C bond formation reaction between diazo compound and alkane catalyzed by dirhodium tetracarboxylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Cyclization reactions involving palladium-catalyzed carbene insertion into aryl halides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Spirastrellolide studies. Synthesis of the C(1)–C(25) southern hemispheres of spirastrellolides A and B, exploiting anion relay chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Silver-catalyzed C-C bond formation between methane and ethyl diazoacetate in supercritical CO₂.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Homogeneous catalysis with methane. A strategy for the hydromethylation of olefins based on the nondegenerate exchange of alkyl groups and sigma-bond metathesis at scandium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Radical-mediated enzymatic methylation: a tale of two SAMS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Biocatalytic Friedel-Crafts alkylation using non-natural cofactors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201303207

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.33.334

Identifiers

DOI

10.1002/ANIE.201303207

1 reference

5 August 2017

1 reference