In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact. (Q35025412)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24155934%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact (English)

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28 February 2020

1

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28 February 2020

Daniel F. Wallace

series ordinal

3

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28 February 2020

Nathan V Subramaniam

series ordinal

4

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28 February 2020

2

Emily M Crampton

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28 February 2020

language of work or name

English

0 references

publication date

14 October 2013

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28 February 2020

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28 February 2020

volume

8

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28 February 2020

issue

10

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28 February 2020

page(s)

e77267

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Creative Commons Attribution 4.0 International

28 February 2020

copyright license

start time

14 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

1 reference

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Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.

8 July 2018

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A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

8 July 2018

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Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

8 July 2018

1 reference

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Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis.

8 July 2018

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Methods for the detection and analysis of protein-protein interactions

8 July 2018

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

8 July 2018

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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

8 July 2018

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First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

8 July 2018

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Overexpression and mislocalization of a tail-anchored GFP redefines the identity of peroxisomal ER.

8 July 2018

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Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells

8 July 2018

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SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.

8 July 2018

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Heterotypic interactions between transferrin receptor and transferrin receptor 2.

8 July 2018

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Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

8 July 2018

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Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

8 July 2018

1 reference

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

8 July 2018

1 reference

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Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

8 July 2018

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Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

8 July 2018

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

8 July 2018

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

8 July 2018

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Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

8 July 2018

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

8 July 2018

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Hepcidin is decreased in TFR2 hemochromatosis

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077267

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077267

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0077267

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24155934

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0077267

1 reference

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28 February 2020

0 references

1 reference

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28 February 2020

1 reference

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