A three-stage biophysical screening cascade for fragment-based drug discovery. (Q35025905)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

A three-stage biophysical screening cascade for fragment-based drug discovery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Ellene H Mashalidis

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Steffen Lang

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Chris Abell

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

publication date

24 October 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

page(s)

2309-2324

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157549%20AND%20SRC:MED&resulttype=core&format=json

The rise of fragment-based drug discovery

28 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment-based approaches to enzyme inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Design of adenosine kinase inhibitors from the NMR-based screening of fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

A fragment-based approach to identifying ligands for riboswitches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Using a Fragment-Based Approach To Target Protein-Protein Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment-based lead discovery grows up.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

From fragment to clinical candidate--a historical perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment-based approaches in drug discovery and chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Protein thermal shifts to identify low molecular weight fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment-based lead discovery using X-ray crystallography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

High-throughput crystallography for lead discovery in drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment screening by surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Applications of ESI-MS in drug discovery: interrogation of noncovalent complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Library design for fragment based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Integration of fragment screening and library design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Route to three-dimensional fragments using diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Natural-product-derived fragments for fragment-based ligand discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Designing a diverse high-quality library for crystallography-based FBDD screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Learning from our mistakes: the 'unknown knowns' in fragment screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

High throughput solubility measurement in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

The effect of freeze/thaw cycles on the stability of compounds in DMSO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

High-density miniaturized thermal shift assays as a general strategy for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Thermofluor-based high-throughput stability optimization of proteins for structural studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Theory and applications of NMR-based screening in pharmaceutical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Fragment-based screening using X-ray crystallography and NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Perspectives on NMR in drug discovery: a technique comes of age

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

STD-NMR: application to transient interactions between biomolecules-a quantitative approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Direct measurement of protein binding energetics by isothermal titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

On the value of c: can low affinity systems be studied by isothermal titration calorimetry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Adding calorimetric data to decision making in lead discovery: a hot tip

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Hydrogen Ion Buffers for Biological Research*

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Presenting your structures: the CCP4mg molecular-graphics software

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

pH and temperature-induced molten globule-like denatured states of equinatoxin II: a study by UV-melting, DSC, far- and near-UV CD spectroscopy, and ANS fluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNPROT.2013.130

Isothermal titration calorimetry.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157549

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FDA approves vemurafenib for treatment of metastatic melanoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157549

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fluorescence-based thermal shift assays

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157549