Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis (Q35028378)

5 August 2017

1 reference

title

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis (English)

1 reference

5 August 2017

1 reference

Sharon S McDaniel

1

1 reference

5 August 2017

Michael Wong

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

24 February 2011

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5 August 2017

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5 August 2017

volume

497

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5 August 2017

issue

3

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5 August 2017

page(s)

231-239

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The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

5 August 2017

cites work

1 reference

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8 July 2018

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8 July 2018

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Rapamycin reduces seizure frequency in tuberous sclerosis complex

8 July 2018

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Do we have a cure for tuberous sclerosis complex?

8 July 2018

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Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis

8 July 2018

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

8 July 2018

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Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

8 July 2018

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Focal brain malformations: a spectrum of disorders along the mTOR cascade.

8 July 2018

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The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

8 July 2018

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

8 July 2018

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Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

8 July 2018

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Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

8 July 2018

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Role of mTOR in physiology and pathology of the nervous system

8 July 2018

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Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation

8 July 2018

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Defining the role of mTOR in cancer

8 July 2018

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Mammalian target of rapamycin: master regulator of cell growth in the nervous system

8 July 2018

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The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.

8 July 2018

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Tuberous sclerosis complex and epilepsy: recent developments and future challenges

8 July 2018

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The growing role of mTOR in neuronal development and plasticity.

8 July 2018

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TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

8 July 2018

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Targeting mammalian target of rapamycin (mTOR) for health and diseases.

8 July 2018

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Anticonvulsant mechanisms of the ketogenic diet

8 July 2018

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The tuberous sclerosis complex

8 July 2018

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RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.

8 July 2018

1 reference

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Therapeutic targets: MTOR and related pathways

8 July 2018

1 reference

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Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury

8 July 2018

1 reference

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Leptin contributes to slower weight gain in juvenile rodents on a ketogenic diet

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway

8 July 2018

1 reference

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Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

8 July 2018

1 reference

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Hamartin and tuberin modulate gene transcription via beta-catenin

8 July 2018

1 reference

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Refractory epilepsy: mechanisms and solutions

8 July 2018

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The outcome of children with intractable seizures: a 3- to 6-year follow-up of 67 children who remained on the ketogenic diet less than one year.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

8 July 2018

1 reference

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Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

8 July 2018

1 reference

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Autophagy and signaling: their role in cell survival and cell death

8 July 2018

1 reference

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Growing roles for the mTOR pathway

8 July 2018

1 reference

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Autophagy: dual roles in life and death?

8 July 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

8 July 2018

1 reference

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Autophagy in health and disease: a double-edged sword

8 July 2018

1 reference

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mTOR: a protein kinase switching between life and death

8 July 2018

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Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis.

8 July 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

8 July 2018

1 reference

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The rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27KIP1.

8 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rheb promotes cell growth as a component of the insulin/TOR signalling network

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Tuberous sclerosis: from tubers to mTOR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

New insights from the use of pilocarpine and kainate models.

8 July 2018

1 reference

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Infantile spasms in tuberous sclerosis complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

The ketogenic diet: a 3- to 6-year follow-up of 150 children enrolled prospectively

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

The upregulation of p27Kip1 by rapamycin results in G1 arrest in exponentially growing T-cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Chronic in vitro ketosis is neuroprotective but not anti-convulsant.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Differential cellular gene expression in ganglioglioma

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin: brain excitability studied in vitro

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rapamycin is a neuroprotective treatment for traumatic brain injury.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Kainic acid induces early and transient autophagic stress in mouse hippocampus

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

A role for the mTOR pathway in surface expression of AMPA receptors.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Glutamatergic regulation of the p70S6 kinase in primary mouse neurons

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

mTOR cascade activation distinguishes tubers from focal cortical dysplasia

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Timing of ketogenic diet initiation in an experimental epilepsy model

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3109223

mTOR in tuberous sclerosis and other neurological disorders

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21354266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Seizure remission and antiepileptic drug discontinuation in children with tuberous sclerosis complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21354266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Are cortical tubers epileptogenic? Evidence from electrocorticography

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21354266

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEULET.2011.02.037

1 reference

5 August 2017

1 reference

5 August 2017

1 reference