Prospects for CD40-directed experimental therapy of human cancer (Q35028895)

5 August 2017

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title

Prospects for CD40-directed experimental therapy of human cancer (English)

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5 August 2017

Alex W Tong

1

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PubMed ID

12489023

5 August 2017

Marvin J Stone

series ordinal

2

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5 August 2017

1 January 2003

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5 August 2017

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5 August 2017

10

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5 August 2017

1

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5 August 2017

1-13

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700527

5 August 2017

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cites work

Identification of a source of biologically active CD40 ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Fas ligation induces apoptosis of CD40-activated human B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Generation of memory B cells and plasma cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

What is the real role of CD40 in cancer immunotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Modulation of cellular responses by plasmid CD40L: CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4+ T cell-mediated protective immunity against herpes simplex virus type 2 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Requirement for CD154 in the progression of atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

The CD40/CD154 receptor/ligand dyad

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Blockade of CD40 ligand suppresses chronic experimental myasthenia gravis by down-regulation of Th1 differentiation and up-regulation of CTLA-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 is functionally expressed on human keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Flow cytometric identification of proliferative subpopulations within normal human epidermis and the localization of the primary hyperproliferative population in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A novel function of CD40: induction of cell death in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Expression of the co-stimulatory molecule CD40 on melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 ligand-induced apoptosis is Fas-independent in human multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Immunologic and hematopoietic effects of CD40 stimulation after syngeneic bone marrow transplantation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

In situ cytokine production by breast cancer tumor-infiltrating lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Production of cytokines and response to them in normal and transformed human mammary epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Molecular basis for CD40 signaling mediated by TRAF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Structural and biochemical analysis of signal transduction by the TRAF family of adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Molecular characterization of CD40 signaling intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Modulation of life and death by the TNF receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Role for CD40-CD40 ligand interactions in the immune response to solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

The TRAIL to selective tumor death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Help for cytotoxic-T-cell responses is mediated by CD40 signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Transgenic expression of CD40L and interleukin-2 induces an autologous antitumor immune response in patients with non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Antitumor immune responses derived from transgenic expression of CD40 ligand in myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Adenovirus-mediated CD40 ligand gene therapy in a rat model of orthotopic hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Thymic overexpression of CD40 ligand disrupts normal thymic epithelial organization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Interleukin-15 as a potential costimulatory cytokine in CD154 gene therapy of chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Role of CD40 in a T cell-mediated negative regulation of Ig production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Human circulating specific antibody-forming cells after systemic and mucosal immunizations: differential homing commitments and cell surface differentiation markers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 and epithelial cells: across the great divide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 expression and function on human dermal microvascular endothelial cells: role in cutaneous inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 and CD95 induce programmed cell death in the human myeloma cell line XG2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Immunologic nonresponsiveness to tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Induction of CTL responses by simultaneous administration of liposomal peptide vaccine with anti-CD40 and anti-CTLA-4 mAb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 ligation for immunotherapy of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Maturation of dendritic cells by recombinant human CD40L-trimer leads to a homogeneous cell population with enhanced surface marker expression and increased cytokine production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD8- dendritic cell activation status plays an integral role in influencing Th2 response development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Regulation of T helper cell differentiation in vivo by soluble and membrane proteins provided by antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40-ligated dendritic cells effectively expand melanoma-specific CD8+ CTLs and CD4+ IFN-gamma-producing T cells from tumor-infiltrating lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Cutting edge: Th2 response induction by dendritic cells: a role for CD40

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Regulation of CD40L expression on natural killer cells by interleukin-12 and interferon gamma: its role in the elicitation of an effective antitumor immune response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Phase I study of recombinant human CD40 ligand in cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

CD40 ligand therapy of lymphoma patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700527

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700527

1 reference

5 August 2017

1 reference

PubMed ID

12489023