Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour (Q35035201)

5 August 2017

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title

Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour (English)

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5 August 2017

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Anthony R Tricker

1

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PubMed ID

12504349

5 August 2017

language of work or name

English

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publication date

1 February 2003

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5 August 2017

23

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inferred from page(s)

published in

Toxicology

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5 August 2017

183

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5 August 2017

1-3

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5 August 2017

151-173

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Two novel mutations of the FMO3 gene in a proband with trimethylaminuria

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Structural characterization of a new variant of the CYP2A6 gene (CYP2A6*1B) apparently diagnosed as heterozygotes of CYP2A6*1A and CYP2A6*4C.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A novel single nucleotide polymorphism altering stability and activity of CYP2a6

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Metabolism of nicotine to cotinine studied by a dual stable isotope method.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Trans-3'-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Smokers of low-yield cigarettes do not consume less nicotine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Deficient C-oxidation of nicotine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Deficient C-oxidation of nicotine continued.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

In vitro-in vivo correlations of human (S)-nicotine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Enzymic oxidation of (-)-nicotine by guinea-pig tissues in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Modelling nicotine intake in smokers and snuff users using biological fluid nicotine metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2D6 genotype and smoking behaviour in cigarette smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The enzyme “aldehyde oxidase” is an iminium oxidase. Reaction with nicotine Δ1′(5′) iminium ion

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Comparison of measured and FTC-predicted nicotine uptake in smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A further study of FTC yield and nicotine absorption in smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Poor metabolisers of nicotine and CYP2D6 polymorphism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2D6 genotypes in cigarette smokers and non-tobacco users

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Simulation and evaluation of nicotine intake during passive smoking: cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Nicotine metabolism and elimination kinetics in newborns

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Accelerated metabolism of nicotine and cotinine in pregnant smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A novel mutant allele of the CYP2A6 gene (CYP2A6*11 ) found in a cancer patient who showed poor metabolic phenotype towards tegafur

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The role of CYP2B6 in human xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The CYP2 A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The metabolism of nicotine-delta 1'(5')-iminium ion, in vivo and in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6 polymorphism, nicotine, and environmental nitrosamines

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6 genetic polymorphisms and liver microsomal coumarin and nicotine oxidation activities in Japanese and Caucasians

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Interindividual variability of coumarin 7-hydroxylation in a Turkish population

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The significance of the homozygous CYP2A6 deletion on nicotine metabolism: a new genotyping method of CYP2A6 using a single PCR-RFLP

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Expression of CYP2A genes in human liver and extrahepatic tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Nicotine metabolism and CYP2A6 allele frequencies in Koreans

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Disposition of nicotine and eight metabolites in smokers and nonsmokers: identification in smokers of two metabolites that are longer lived than cotinine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Characterization of cytochrome P450 expression in human oesophageal mucosa.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Genetic variation of CYP2A6, smoking, and risk of cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Simultaneous determination of nicotine and eight nicotine metabolites in urine of smokers using liquid chromatography-tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6 gene deletion reduces susceptibility to lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Pharmacokinetics of nicotine in kidney failure

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Pharmacokinetics of nicotine in healthy elderly people

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Relationship between interindividual differences in nicotine metabolism and CYP2A6 genetic polymorphism in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies*

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Homologous unequal cross-over within the human CYP2A gene cluster as a mechanism for the deletion of the entire CYP2A6 gene associated with the poor metabolizer phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Hepatitis A impairs the function of human hepatic CYP2A6 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Nicotine metabolism and intake in black and white smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Nicotine metabolism defect reduces smoking.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Coumarin 7-hydroxylation in long-term adherents of a strict uncooked vegan diet

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Genetic influences on smoking: candidate genes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Cigarette Smoking: A Dependence on High-Nicotine Boli

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2D6 ultrarapid metabolizer genotype as a potential modifier of smoking behaviour.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Smoking behaviour and compensation: a review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Lack of correlation between CYP2A6 genotype and smoking habits.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Variables affecting nicotine metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Pharmacogenetics and ethnoracial differences in smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

CYP2A6 genotype and smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Cotinine levels in Southeast Asian smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

Clinical pharmacology of oral cotinine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2802%2900513-9

7 January 2021

10.1016/S0300-483X(02)00513-9

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12504349