Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition. (Q35044902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

3

1 reference

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1 March 2020

author name string

X Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

J M Makarewicz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

L K Johnson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

J A Fagin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

language of work or name

English

0 references

publication date

18 November 2013

1 reference

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1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

47

1 reference

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1 March 2020

page(s)

5442-5449

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

Mutant and wild-type Ras: co-conspirators in cancer

1 March 2020

cites work

1 reference

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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

8 July 2018

1 reference

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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

8 July 2018

1 reference

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Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.

8 July 2018

1 reference

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Regulating the regulator: post-translational modification of RAS

8 July 2018

1 reference

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RAS oncogenes: weaving a tumorigenic web

8 July 2018

1 reference

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Functional specificity of ras isoforms: so similar but so different

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Oncogenic activating mutations are associated with local copy gain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Ras oncogenes: split personalities

8 July 2018

1 reference

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A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Tumour maintenance is mediated by eNOS.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Hyperactive Ras in developmental disorders and cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Inhibition of Ras oncogenic activity by Ras protooncogenes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Farnesyl transferase inhibitors for patients with lung cancer

8 July 2018

1 reference

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Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Wildtype Kras2 can inhibit lung carcinogenesis in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

8 July 2018

1 reference

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Predisposition to neoplastic transformation caused by gene replacement of H-ras1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Differential expression of the ras gene family in mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

p21ras is modified by a farnesyl isoprenoid

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

H-ras protooncogene mutations in human thyroid neoplasms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025988

A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older.

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.489

Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.489

High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.489

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.489

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.489

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24240680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24240680

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2013.489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

24240680

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24240680%20AND%20SRC:MED&resulttype=core&format=json