Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity (Q35049771)

6 August 2017

Pathobiology and potential therapeutic value of intestinal short-chain fatty acids in gut inflammation and obesity (English)

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6 August 2017

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2

Jonathan D Kaunitz

1 reference

6 August 2017

Jessica Soldavini

1

1 reference

6 August 2017

10 July 2013

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Digestive Diseases and Sciences

6 August 2017

1 reference

6 August 2017

58

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6 August 2017

10

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6 August 2017

2756-2766

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https://scigraph.springernature.com/pub.10.1007/s10620-013-2744-4

6 August 2017

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Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms

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Comparison of prophylactic and therapeutic use of short-chain fatty acid enemas in diversion colitis: a study in Wistar rats

8 July 2018

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The bacterial pathogenesis and treatment of pouchitis

8 July 2018

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Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission.

8 July 2018

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Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats

8 July 2018

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8 July 2018

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8 July 2018

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Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids

8 July 2018

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8 July 2018

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Sodium-coupled monocarboxylate transporters in normal tissues and in cancer

8 July 2018

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Probiotics for induction of remission in ulcerative colitis

8 July 2018

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Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease

8 July 2018

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Inflammatory bowel disease: clinical aspects and established and evolving therapies

8 July 2018

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Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

8 July 2018

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Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats

8 July 2018

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Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT

8 July 2018

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Colonic health: fermentation and short chain fatty acids

8 July 2018

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Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats

8 July 2018

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Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine

8 July 2018

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SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter

8 July 2018

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Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition

8 July 2018

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Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43

8 July 2018

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Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial

8 July 2018

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Effects of feeding a probiotic preparation (SIM) containing inulin on the severity of colitis and on the composition of the intestinal microflora in HLA-B27 transgenic rats

8 July 2018

1 reference

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Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids

8 July 2018

1 reference

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Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

8 July 2018

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Glucagon-Like Peptide-2 and Short-Chain Fatty Acids: A New Twist to an Old Story

8 July 2018

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Galacto-oligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Histone deacetylases and cancer: causes and therapies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Prebiotic digestion and fermentation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Identification of a monocarboxylate transporter isoform type 1 (MCT1) on the luminal membrane of human and pig colon.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

The contribution of the large intestine to energy supplies in man

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Short chain fatty acids in human large intestine, portal, hepatic and venous blood

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Energy contributions of volatile fatty acids from the gastrointestinal tract in various species

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Nutrient utilization by cells isolated from rat jejunum, cecum and colon

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Effect of short-chain fatty acids on the human colonic mucosa in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Experimental short-bowel syndrome: effect of an elemental diet supplemented with short-chain triglycerides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Short-chain fatty acid enemas: a cost-effective alternative in the treatment of nonspecific proctosigmoiditis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Effect of organic acid absorption on bicarbonate transport in rat colon

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Three distinct mechanisms of HCO3- secretion in rat distal colon

8 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Short communication: Presence of G protein-coupled receptor 43 in rumen epithelium but not in the islets of Langerhans in cattle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Regulation of adipokine production in human adipose tissue by propionic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Mediators of glucagon-like peptide 2-induced blood flow: responses in different vascular sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Low counts of Faecalibacterium prausnitzii in colitis microbiota.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Molecular characterization of rectal mucosa-associated bacterial flora in inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

New prebiotics from rice bran ameliorate inflammation in murine colitis models through the modulation of intestinal homeostasis and the mucosal immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Randomized placebo-controlled trial assessing the effect of bifidobacteria-fermented milk on active ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Restoration of the integrity of rat caeco-colonic mucosa by resistant starch, but not by fructo-oligosaccharides, in dextran sulfate sodium-induced experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Oligosaccharides isolated from goat milk reduce intestinal inflammation in a rat model of dextran sodium sulfate-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Protective effect of lactulose on dextran sulfate sodium-induced colonic inflammation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Preventative effects of lactulose in the trinitrobenzenesulphonic acid model of rat colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Probiotics and blueberry attenuate the severity of dextran sulfate sodium (DSS)-induced colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Combined oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis: randomized, double-blind, placebo-controlled pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Expression of the short-chain fatty acid receptor, GPR43, in the human colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Combined butyric acid/mesalazine treatment in ulcerative colitis with mild-moderate activity. Results of a multicentre pilot study.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Comparison of fermentation reactions in different regions of the human colon

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317286

Oral oligofructose-enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin

25 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Consumption of Breads Containing In Situ–Produced Arabinoxylan Oligosaccharides Alters Gastrointestinal Effects in Healthy Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10620-013-2744-4

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

21 January 2018

1 reference

12 December 2020

Kinetics of butyrate metabolism in the normal colon and in ulcerative colitis: the effects of substrate concentration and carnitine on the β-oxidation pathway

1 reference

12 December 2020

Predictive factors of GI lesions in 241 women with iron deficiency anemia

1 reference

12 December 2020

Beneficial effects of probiotic bifidobacterium and galacto-oligosaccharide in patients with ulcerative colitis: a randomized controlled study

1 reference

12 December 2020

Treatment of diversion colitis by short-chain fatty acids. Prospective and double-blind study

1 reference

12 December 2020

Treatment of diversion colitis with short-chain-fatty acid irrigation

1 reference

12 December 2020

Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study

1 reference

12 December 2020

Fermentation in the human large intestine and the available substrates

1 reference

12 December 2020

Fructo-oligosaccharide reduces inflammation in a dextran sodium sulphate mouse model of colitis

1 reference

12 December 2020

Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis

1 reference

12 December 2020

The characterization of butyrate transport across pig and human colonic luminal membrane

1 reference

12 December 2020

Short-chain fatty acid-supplemented total parenteral nutrition enhances functional adaptation to intestinal resection in rats

1 reference

12 December 2020

Short-chain fatty acids in pouch contents from patients with and without pouchitis after ileal pouch-anal anastomosis

1 reference

12 December 2020

Topical treatment of refractory distal ulcerative colitis with 5-ASA and sodium butyrate

1 reference

12 December 2020

The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats

1 reference

12 December 2020

Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats

1 reference

12 December 2020

Rectal irrigation with short-chain fatty acids for distal ulcerative colitis. Preliminary report

1 reference

12 December 2020

A comparative study of the preventative effects exerted by two probiotics, Lactobacillus reuteri and Lactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis

1 reference

12 December 2020

Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial. German-Austrian SCFA Study Group

1 reference

12 December 2020

Short-chain fatty acid irrigation in severe pouchitis

1 reference

12 December 2020

A relation between the chain length of fatty acids and the slowing of gastric emptying

1 reference

12 December 2020

Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis

1 reference

12 December 2020

Isolation and characterisation of new putative probiotic bacteria from human colonic flora

1 reference

12 December 2020

Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum

1 reference

12 December 2020

Treatment of left-sided ulcerative colitis with butyrate enemas: a controlled trial

1 reference

12 December 2020

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

1 reference

12 December 2020

Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas

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12 December 2020

The role of carbohydrates in lower gut function

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12 December 2020

Short-chain fatty acids increase proglucagon and ornithine decarboxylase messenger RNAs after intestinal resection in rats

1 reference

12 December 2020

10.1007/S10620-013-2744-4

Identifiers

DOI

1 reference

6 August 2017

1 reference

6 August 2017

1 reference

PubMed ID

23839339