PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity (Q35056063)

6 August 2017

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title

PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity (English)

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6 August 2017

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Zhong-Yin Zhang

1

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PubMed ID

12556216

6 August 2017

Seung-Yub Lee

series ordinal

2

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PubMed ID

12556216

6 August 2017

language of work or name

English

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publication date

1 February 2003

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Expert Opinion on Investigational Drugs

6 August 2017

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6 August 2017

12

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6 August 2017

223-233

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6 August 2017

2

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Signaling--2000 and beyond

6 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatases in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatases: prospects for therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Deconstructing type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Obesity and the regulation of energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Insulin signal transduction through protein kinase cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Insulin signaling pathways in time and space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Activation of phosphatidylinositol 3-kinase by insulin

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

GSK3 takes centre stage more than 20 years after its discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Banting lecture 1988. Role of insulin resistance in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

From Vanadis to Atropos: vanadium compounds as pharmacological tools in cell death signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatases: their role in insulin action and potential as drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatase 1B interacts with the activated insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Dynamics of protein-tyrosine phosphatases in rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Abnormal Regulation of Protein Tyrosine Phosphatase Activities in Skeletal Muscle of Insulin-Resistant Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Pharmacologic therapy for type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Role of leptin in the neuroendocrine response to fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Divergent signaling capacities of the long and short isoforms of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

A synthetic peptide derived from a COOH-terminal domain of the insulin receptor specifically enhances insulin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Colworth Medal Lecture. Structural studies of reversible protein phosphorylation and protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Substrate specificity of the protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.2.223

10.1517/13543784.12.2.223

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12556216