Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1 (Q35060701)

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English	Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1 (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Herpes simplex virus type 1

1 reference

based on heuristic

inferred from title

author name string

David C Gaston

1

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Carl I Odom

2

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Europe PubMed Central

PubMed publication ID

6 August 2017

Li Li

3

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

James M Markert

4

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Justin C Roth

5

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Kevin A Cassady

6

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Richard J Whitley

7

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Europe PubMed Central

PubMed publication ID

6 August 2017

Jacqueline N Parker

8

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Europe PubMed Central

PubMed publication ID

6 August 2017

language of work or name

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publication date

27 November 2013

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Europe PubMed Central

PubMed publication ID

6 August 2017

8

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Europe PubMed Central

PubMed publication ID

6 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

e81768

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Europe PubMed Central

PubMed publication ID

6 August 2017

copyright license

Creative Commons Attribution 3.0 Unported

27 November 2013

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April 2022 Public Data File from Crossref

copyright status

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Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer

1 reference

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1 reference

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

1 reference

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Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame

1 reference

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Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum

1 reference

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Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist

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Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice

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Myxoma virus expressing interleukin-15 fails to cause lethal myxomatosis in European rabbits.

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Potential for efficacy of the oncolytic Herpes simplex virus 1716 in patients with oral squamous cell carcinoma

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How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha

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Twelve immunotherapy drugs that could cure cancers

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Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

1 reference

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Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

1 reference

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Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses

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Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

1 reference

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Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal

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Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

1 reference

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1 reference

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1 reference

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1 reference

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Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24312353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0081768

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

2013PLoSO...881768G

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

ResearchGate publication ID

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