Glucotoxicity and beta-cell failure in type 2 diabetes mellitus (Q35065639)

6 August 2017

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title

Glucotoxicity and beta-cell failure in type 2 diabetes mellitus (English)

1 reference

6 August 2017

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Nurit Kaiser

1

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PubMed ID

12585335

6 August 2017

Gil Leibowitz

series ordinal

2

1 reference

PubMed ID

12585335

6 August 2017

Rafael Nesher

series ordinal

3

1 reference

6 August 2017

1 January 2003

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Journal of Pediatric Endocrinology and Metabolism

6 August 2017

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6 August 2017

16

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6 August 2017

5-22

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6 August 2017

1

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Global and societal implications of the diabetes epidemic

6 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Mechanisms of action of nonglucose insulin secretagogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

GTP-binding proteins and regulated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

SNAREs and SNARE regulators in membrane fusion and exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The synaptic vesicle cycle revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Mechanisms of vesicle formation: insights from the COP system

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Secretory granule biogenesis: rafting to the SNARE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Maternal transmission of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Diabetes mellitus and genetically programmed defects in beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Type 2 diabetes, the thrifty phenotype - an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Characterization of stages in development of obesity-diabetes syndrome in sand rat (Psammomys obesus)

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Beta-cell protein kinases and the dynamics of the insulin response to glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Vascular targets of redox signalling in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Regulation of insulin gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose stimulation of the proinsulin synthesis in isolated pancreatic islets without increasing amount of proinsulin mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Short-term regulation of insulin gene transcription by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

21 January 2018

Transcribing pancreas.

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Pancreatic organogenesis--developmental mechanisms and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Insulin-promoter-factor 1 is required for pancreas development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Islet growth and development in the adult

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Replication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Human type 2 diabetes: morphological evidence for abnormal beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Induction of Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients by Transient Intensive Insulin Treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

Glucose and RNA Synthesis in Mammalian Islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FJPEM.2003.16.1.5

21 January 2018

Identifiers

DOI

10.1515/JPEM.2003.16.1.5

1 reference

6 August 2017

1 reference

PubMed ID

12585335