Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. (Q35084950)

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English	Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation.	scientific article

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23 February 2020

Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation (English)

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23 February 2020

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colorectal cancer

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Amit Deorukhkar

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23 February 2020

Pranshu Mohindra

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23 February 2020

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Niharika Ahuja

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23 February 2020

Armando-Lopez Mercado

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23 February 2020

Parmeswaran Diagaradjane

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23 February 2020

Uma Raju

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23 February 2020

Nalini Patel

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23 February 2020

Nga Diep

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23 February 2020

Sushovan Guha

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23 February 2020

Sunil Krishnan

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23 February 2020

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1 December 2014

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23 February 2020

Cancer Medicine

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23 February 2020

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23 February 2020

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23 February 2020

278-292

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23 February 2020

Colorectal cancer statistics, 2014.

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8 July 2018

Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma

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Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro

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DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy

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Repair of double-strand breaks by end joining

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8 July 2018

Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis

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8 July 2018

Reduced glutathione: a radioprotector or a modulator of DNA-repair activity?

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Molecular targets and mechanisms of radiosensitization using DNA damage response pathways

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Nuclear glutathione

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8 July 2018

Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer.

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8 July 2018

Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization

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8 July 2018

Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway

1 reference

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8 July 2018

Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.

1 reference

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8 July 2018

Attractive reactivity of a natural product, zerumbone

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8 July 2018

Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells

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8 July 2018

A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells

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8 July 2018

gammaH2AX: a sensitive molecular marker of DNA damage and repair

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8 July 2018

Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03.

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8 July 2018

Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity

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8 July 2018

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

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8 July 2018

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

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8 July 2018

Glutathione: overview of its protective roles, measurement, and biosynthesis

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8 July 2018

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation

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8 July 2018

Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway

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8 July 2018

Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203.

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8 July 2018

Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib

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8 July 2018

Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

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8 July 2018

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

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8 July 2018

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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8 July 2018

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SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

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Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite.

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12 December 2020

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Suberoyl bishydroxamic acid-induced apoptosis in HeLa cells via ROS-independent, GSH-dependent manner

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12 December 2020

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Radiosensitization with 5-Bromodeoxyuridine of Chinese Hamster Cells X-Irradiated during Different Phases of the Cell Cycle

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Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer

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12 December 2020

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10.1002/CAM4.367

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23 February 2020

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23 February 2020

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23 February 2020

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