The ATM protein kinase: regulating the cellular response to genotoxic stress, and more (Q38088935)

28 August 2017

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. (English)

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28 August 2017

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Yosef Shiloh

1

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PubMed ID

23486281

28 August 2017

Yael Ziv

series ordinal

2

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28 August 2017

13 March 2013

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Nature Reviews Molecular Cell Biology

28 August 2017

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28 August 2017

14

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28 August 2017

197-210

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28 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrm3546

28 August 2017

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cites work

Ataxia-telangiectasia

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ATM and the molecular pathogenesis of ataxia telangiectasia

31 March 2020

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Mechanisms of replication fork protection: a safeguard for genome stability

31 March 2020

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Posttranslational control of telomere maintenance and the telomere damage response.

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

1 reference

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

31 March 2020

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ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage

31 March 2020

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Common mechanisms of PIKK regulation

31 March 2020

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Emerging common themes in regulation of PIKKs and PI3Ks

31 March 2020

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ATM protein kinase: the linchpin of cellular defenses to stress

31 March 2020

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The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

31 March 2020

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Choosing the right path: does DNA-PK help make the decision?

31 March 2020

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Emerging roles of DNA-PK besides DNA repair

31 March 2020

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New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

31 March 2020

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ATR signalling: more than meeting at the fork

31 March 2020

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ATR: an essential regulator of genome integrity

31 March 2020

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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

31 March 2020

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Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling

31 March 2020

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Differential function of NBS1 and ATR in neurogenesis.

31 March 2020

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ATR maintains select progenitors during nervous system development

31 March 2020

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

31 March 2020

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Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

31 March 2020

1 reference

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

31 March 2020

1 reference

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

31 March 2020

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ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

31 March 2020

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Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

31 March 2020

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The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

31 March 2020

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

31 March 2020

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

31 March 2020

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

31 March 2020

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

31 March 2020

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

31 March 2020

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Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

31 March 2020

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Involvement of novel autophosphorylation sites in ATM activation

31 March 2020

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Autophosphorylation and ATM activation: additional sites add to the complexity

31 March 2020

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

31 March 2020

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DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

31 March 2020

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

31 March 2020

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

31 March 2020

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ATM activation and DNA damage response

31 March 2020

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Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

31 March 2020

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Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

31 March 2020

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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

31 March 2020

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Activation of the cellular DNA damage response in the absence of DNA lesions

31 March 2020

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Rapid activation of ATM on DNA flanking double-strand breaks

31 March 2020

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Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks

31 March 2020

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Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

31 March 2020

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The MRE11 complex: starting from the ends.

31 March 2020

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

31 March 2020

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The NBS1-ATM connection revisited

31 March 2020

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The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

31 March 2020

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Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

31 March 2020

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53BP1 promotes ATM activity through direct interactions with the MRN complex

31 March 2020

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Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

31 March 2020

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PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

31 March 2020

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

31 March 2020

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

31 March 2020

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

31 March 2020

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ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control

31 March 2020

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

31 March 2020

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

31 March 2020

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Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

31 March 2020

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Oligomerization of MDC1 protein is important for proper DNA damage response

31 March 2020

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Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

31 March 2020

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The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

31 March 2020

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Aven-dependent activation of ATM following DNA damage

31 March 2020

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Functional interaction between FOXO3a and ATM regulates DNA damage response

31 March 2020

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Involvement of human MOF in ATM function

31 March 2020

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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

31 March 2020

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Chfr and RNF8 synergistically regulate ATM activation

31 March 2020

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

31 March 2020

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Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

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The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

31 March 2020

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Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

31 March 2020

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Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue

31 March 2020

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Transcriptional modulation induced by ionizing radiation: p53 remains a central player

31 March 2020

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Human fibroblasts for large-scale "omics" investigations of ATM gene function

31 March 2020

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Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes

31 March 2020

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Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

31 March 2020

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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

31 March 2020

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Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

31 March 2020

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Akt: a double-edged sword in cell proliferation and genome stability

31 March 2020

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HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

31 March 2020

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Beyond ATM: the protein kinase landscape of the DNA damage response

31 March 2020

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

31 March 2020

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The DNA Damage Response: Making It Safe to Play with Knives

31 March 2020

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Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

31 March 2020

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New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy

31 March 2020

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The p53 network: cellular and systemic DNA damage responses in aging and cancer

31 March 2020

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DNA damage induces phosphorylation of the amino terminus of p53

31 March 2020

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Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage

31 March 2020

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Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

31 March 2020

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DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.

31 March 2020

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PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

31 March 2020

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

31 March 2020

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ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

31 March 2020

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Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

31 March 2020

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

31 March 2020

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CtIP links DNA double-strand break sensing to resection

31 March 2020

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ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

31 March 2020

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Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

31 March 2020

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Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

31 March 2020

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ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability

31 March 2020

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ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

31 March 2020

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

31 March 2020

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

31 March 2020

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The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

31 March 2020

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KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

31 March 2020

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Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

31 March 2020

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Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.

31 March 2020

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Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

31 March 2020

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The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage

31 March 2020

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The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

31 March 2020

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ATM mediated phosphorylation of CHD4 contributes to genome maintenance

31 March 2020

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Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism

31 March 2020

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Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

31 March 2020

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

31 March 2020

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DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks.

31 March 2020

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The ATM kinase induces microRNA biogenesis in the DNA damage response.

31 March 2020

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Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents

31 March 2020

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Enhanced sensitivity to camptothecin in ataxia-telangiectasia cells and its relationship with the expression of DNA topoisomerase I.

31 March 2020

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Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

31 March 2020

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

31 March 2020

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Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

31 March 2020

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ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation

31 March 2020

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Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

31 March 2020

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ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation

31 March 2020

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

31 March 2020

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Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

31 March 2020

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Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

31 March 2020

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Oxygen sensing and the DNA-damage response

31 March 2020

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ATM activation and signaling under hypoxic conditions.

31 March 2020

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Targeting hypoxic cells through the DNA damage response

31 March 2020

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Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status

31 March 2020

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ATMIN defines an NBS1-independent pathway of ATM signalling

31 March 2020

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Competition between NBS1 and ATMIN controls ATM signaling pathway choice

31 March 2020

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Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint

31 March 2020

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The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

31 March 2020

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Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors

31 March 2020

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ATM binds to beta-adaptin in cytoplasmic vesicles

31 March 2020

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Localization of a portion of extranuclear ATM to peroxisomes

31 March 2020

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Cytoplasmic ATM in neurons modulates synaptic function

31 March 2020

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The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

31 March 2020

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Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells

31 March 2020

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Defective potassium currents in ataxia telangiectasia fibroblasts

31 March 2020

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Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents

31 March 2020

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Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts.

31 March 2020

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Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase

31 March 2020

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Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.

31 March 2020

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Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism.

31 March 2020

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A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway

31 March 2020

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Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration

31 March 2020

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Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

31 March 2020

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ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

31 March 2020

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Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

31 March 2020

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

31 March 2020

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ATM activation by oxidative stress

31 March 2020

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ATM activation in the presence of oxidative stress

31 March 2020

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The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle

31 March 2020

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ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

31 March 2020

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mTOR signaling in growth control and disease

31 March 2020

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

31 March 2020

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Differential localization of ATM is correlated with activation of distinct downstream signaling pathways

31 March 2020

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mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

31 March 2020

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Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells

31 March 2020

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Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

31 March 2020

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Mitochondrial dysfunction in ataxia-telangiectasia

31 March 2020

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Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

31 March 2020

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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

31 March 2020

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Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice

31 March 2020

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Late degeneration of nigro-striatal neurons in ATM-/- mice.

31 March 2020

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Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.

31 March 2020

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Reduced synchronization persistence in neural networks derived from atm-deficient mice.

31 March 2020

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Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

31 March 2020

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A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia

31 March 2020

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

31 March 2020

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The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

31 March 2020

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Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

31 March 2020

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

31 March 2020

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Coping with DNA double strand breaks

31 March 2020

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

31 March 2020

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Focus on histone variant H2AX: to be or not to be.

31 March 2020

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DNA double-strand break repair pathways, chromosomal rearrangements and cancer

31 March 2020

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Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways

31 March 2020

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Playing the end game: DNA double-strand break repair pathway choice

31 March 2020

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Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors

31 March 2020

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

31 March 2020

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Loss of ATM kinase activity leads to embryonic lethality in mice

31 March 2020

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SPIKE: a database of highly curated human signaling pathways

31 March 2020

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The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage

31 March 2020

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ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage

31 March 2020

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DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.

31 March 2020

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Regulation of SIRT1 activity by genotoxic stress

31 March 2020

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ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage

31 March 2020

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53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage

31 March 2020

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12 December 2020

A ROS rheostat for cell fate regulation

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12 December 2020

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair

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12 December 2020

Rejuvenating Bi(d)ology

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12 December 2020

Induction of p53 and increased sensitivity to cisplatin in ataxia-telangiectasia cells

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12 December 2020

Pathological neoangiogenesis depends on oxidative stress regulation by ATM.

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12 December 2020

The p53 circuit board

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12 December 2020

NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks

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12 December 2020

Nuclear retention of ATM at sites of DNA double strand breaks

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12 December 2020

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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12 December 2020

Identifiers

DOI

10.1038/NRM3546

1 reference

PubMed ID

23486281

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23486281