SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization (Q33195747)

23 July 2017

title

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization (English)

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23 July 2017

Ismail Hassan Ismail

1

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23 July 2017

Susanne Mårtensson

2

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23 July 2017

Deborah Moshinsky

3

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23 July 2017

Audie Rice

4

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23 July 2017

Cho Tang

5

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23 July 2017

Anthony Howlett

6

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23 July 2017

Gerald McMahon

7

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23 July 2017

Ola Hammarsten

8

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23 July 2017

language of work or name

English

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publication date

1 January 2004

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23 July 2017

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23 July 2017

volume

23

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23 July 2017

issue

4

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23 July 2017

page(s)

873-882

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

23 July 2017

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

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Activation of DNA-dependent protein kinase by single-stranded DNA ends

21 January 2018

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Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation.

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DNA-dependent protein kinase catalytic subunit. Structural requirements for kinase activation by DNA ends

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

21 January 2018

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Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases

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DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin

21 January 2018

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The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway

21 January 2018

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Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation

21 January 2018

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Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

21 January 2018

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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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7 January 2021

Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks

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7 January 2021

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

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7 January 2021

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

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7 January 2021

Cleavage of cellular DNA by calicheamicin gamma1.

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7 January 2021

Radiation-induced double-strand breaks in mammalian DNA: influence of temperature and DMSO.

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7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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7 January 2021

Cross-resistance to ionizing radiation in a murine leukemic cell line resistant to cis-dichlorodiammineplatinum(II): role of Ku autoantigen.

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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7 January 2021

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

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7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

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7 January 2021

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

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7 January 2021

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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7 January 2021

Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

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7 January 2021

Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

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7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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7 January 2021

Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks

1 reference

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7 January 2021

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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7 January 2021

The Akt kinase signals directly to endothelial nitric oxide synthase

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7 January 2021

Molecular genetic characterization of XRCC4 function

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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7 January 2021

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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7 January 2021

IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system

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7 January 2021

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint

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7 January 2021

ATM and ATR: networking cellular responses to DNA damage

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7 January 2021

DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity

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7 January 2021

Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: results for cells deficient in nonhomologous end joining

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7 January 2021

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

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7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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7 January 2021

OK-1035, a selective inhibitor of DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207303

7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207303

7 January 2021

Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207303

7 January 2021

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207303

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207303

1 reference

Dimensions Publication ID

23 July 2017

1030913453

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1 reference