Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins (Q35094005)

6 August 2017

title

Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins (English)

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6 August 2017

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9

Susan Lindquist

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6 August 2017

7

Bonnie Berger

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6 August 2017

6

Oliver D King

1 reference

6 August 2017

Randal Halfmann

1

1 reference

6 August 2017

Simon Alberti

2

1 reference

6 August 2017

Rajaraman Krishnan

3

1 reference

6 August 2017

Nicholas Lyle

4

1 reference

6 August 2017

Charles W O'Donnell

5

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6 August 2017

Rohit V Pappu

8

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6 August 2017

publication date

1 July 2011

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6 August 2017

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6 August 2017

volume

43

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6 August 2017

issue

1

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6 August 2017

page(s)

72-84

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Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins

6 August 2017

cites work

1 reference

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Optical trapping with high forces reveals unexpected behaviors of prion fibrils

9 July 2018

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In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells

9 July 2018

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Functional amyloid in Pseudomonas

9 July 2018

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Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

9 July 2018

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The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.

9 July 2018

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Regulation of synaptic Pumilio function by an aggregation-prone domain

9 July 2018

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Prions, protein homeostasis, and phenotypic diversity

9 July 2018

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Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

9 July 2018

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The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system

9 July 2018

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Compositional determinants of prion formation in yeast

9 July 2018

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Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation

9 July 2018

1 reference

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Predicting intrinsic disorder in proteins: an overview

9 July 2018

1 reference

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Thermodynamics of beta-sheet formation in polyglutamine

9 July 2018

1 reference

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The functional curli amyloid is not based on in-register parallel beta-sheet structure

9 July 2018

1 reference

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Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].

9 July 2018

1 reference

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Amyloid deposits: protection against toxic protein species?

9 July 2018

1 reference

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A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

9 July 2018

1 reference

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The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

9 July 2018

1 reference

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Simulations of nucleation and elongation of amyloid fibrils

9 July 2018

1 reference

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Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

9 July 2018

1 reference

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Malleable machines take shape in eukaryotic transcriptional regulation

9 July 2018

1 reference

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P bodies promote stress granule assembly in Saccharomyces cerevisiae

9 July 2018

1 reference

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Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

The Zyggregator method for predicting protein aggregation propensities

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Amyloidogenesis of natively unfolded proteins

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

9 July 2018

Amyloids: friend or foe?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Amyloid adhesins are abundant in natural biofilms

9 July 2018

1 reference

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Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae

9 July 2018

1 reference

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

9 July 2018

1 reference

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A polymer physics perspective on driving forces and mechanisms for protein aggregation

9 July 2018

1 reference

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Quantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theories

9 July 2018

1 reference

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Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains

9 July 2018

1 reference

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A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures.

9 July 2018

1 reference

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Polymorphism in the intermediates and products of amyloid assembly

9 July 2018

1 reference

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Intrinsic disorder and functional proteomics

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

A network of protein interactions determines polyglutamine toxicity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Recent atomic models of amyloid fibril structure

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Transcriptional activators in yeast

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Prion domains: sequences, structures and interactions

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Primary sequence independence for prion formation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Structural insights into a yeast prion illuminate nucleation and strain diversity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Hyper-expansion of asparagines correlates with an abundance of proteins with prion-like domains in Plasmodium falciparum

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Dissection and design of yeast prions

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

A neuronal isoform of the aplysia CPEB has prion-like properties

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Yeast [PSI+] Prion Aggregates Are Formed by Small Sup35 Polymers Fragmented by Hsp104

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

The architecture of parallel beta-helices and related folds

9 July 2018

1 reference

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Prions affect the appearance of other prions: the story of [PIN(+)].

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Sequence complexity of disordered protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions

9 July 2018

1 reference

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A yeast prion provides a mechanism for genetic variation and phenotypic diversity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Nucleated conformational conversion and the replication of conformational information by a prion determinant

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Evidence for a protein mutator in yeast: role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae.

9 July 2018

1 reference

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Predicting coiled coils from protein sequences

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Rate of beta-structure formation in polypeptides

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

9 July 2018

1 reference

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Paircoil2: improved prediction of coiled coils from sequence.

27 September 2018

1 reference

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Characterizing the conformational ensemble of monomeric polyglutamine.

27 September 2018

1 reference

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Is the prion domain of soluble Ure2p unstructured?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Reduced amino acid alphabet is sufficient to accurately recognize intrinsically disordered protein.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132398

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.

27 September 2018

1 reference

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Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

27 September 2018

1 reference

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Glutamine-rich domains activate transcription in yeast Saccharomyces cerevisiae

27 September 2018

1 reference

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Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits

27 September 2018

1 reference

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Effects of ubiquitin system alterations on the formation and loss of a yeast prion

16 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21726811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2011.05.013

1 reference

6 August 2017

1 reference

6 August 2017

1 reference