DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes (Q35098038)

6 August 2017

title

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes (English)

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6 August 2017

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16

Josephine M Egan

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19

Mark P Mattson

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6 August 2017

20

Vilhelm A Bohr

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6 August 2017

Peter Sykora

1

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6 August 2017

Magdalena Misiak

2

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6 August 2017

Yue Wang

3

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6 August 2017

Somnath Ghosh

4

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6 August 2017

Giovana S Leandro

5

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6 August 2017

Dong Liu

6

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6 August 2017

Jane Tian

7

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6 August 2017

Beverly A Baptiste

8

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6 August 2017

Wei-Na Cong

9

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6 August 2017

Boris M Brenerman

10

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6 August 2017

Evandro Fang

11

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6 August 2017

Kevin G Becker

12

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6 August 2017

Royce J Hamilton

13

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6 August 2017

Soumya Chigurupati

14

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6 August 2017

Yongqing Zhang

15

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6 August 2017

Deborah L Croteau

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6 August 2017

David M Wilson

18

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6 August 2017

language of work or name

English

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publication date

30 December 2014

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6 August 2017

published in

Nucleic Acids Research

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6 August 2017

volume

43

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6 August 2017

issue

2

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6 August 2017

page(s)

943-959

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DNA damage and its links to neurodegeneration

6 August 2017

cites work

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9 July 2018

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Alzheimer's disease-associated neurotoxic peptide amyloid-β impairs base excision repair in human neuroblastoma cells

9 July 2018

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9 July 2018

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9 July 2018

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Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

9 July 2018

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9 July 2018

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RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease

9 July 2018

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Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

9 July 2018

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2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

9 July 2018

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Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity

9 July 2018

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Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

9 July 2018

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9 July 2018

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9 July 2018

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Variation in base excision repair capacity

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.

9 July 2018

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Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

9 July 2018

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9 July 2018

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DNA Damage, Aging, and Cancer

9 July 2018

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

9 July 2018

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Direct and indirect roles of RECQL4 in modulating base excision repair capacity

9 July 2018

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9 July 2018

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9 July 2018

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DNA polymerase beta-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain

9 July 2018

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Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease.

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

9 July 2018

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Oxidatively modified RNA in mild cognitive impairment

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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DNA oxidation in Alzheimer's disease

9 July 2018

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Gene regulation and DNA damage in the ageing human brain

9 July 2018

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What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies

9 July 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

9 July 2018

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Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

9 July 2018

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Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice

9 July 2018

1 reference

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Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

9 July 2018

1 reference

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DNA polymerase-beta may be the main player for defective DNA repair in aging rat neurons

9 July 2018

1 reference

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

9 July 2018

1 reference

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Oxidants, oxidative stress and the biology of ageing

9 July 2018

1 reference

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Rates of hippocampal atrophy correlate with change in clinical status in aging and AD.

9 July 2018

1 reference

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Oxidative phosphorylation defects and Alzheimer's disease

9 July 2018

1 reference

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Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

9 July 2018

1 reference

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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

9 July 2018

1 reference

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Studies on DNA repair defects in degenerative brain disease

9 July 2018

1 reference

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

9 July 2018

1 reference

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Alzheimer's disease in Down's syndrome: clinicopathologic studies

9 July 2018

1 reference

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The topography of plaques and tangles in Down's syndrome patients of different ages

9 July 2018

1 reference

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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

9 July 2018

1 reference

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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

9 July 2018

1 reference

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NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease

27 September 2018

1 reference

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Aβ secretion and plaque formation depend on autophagy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

High-throughput comet assay using 96 minigels

27 September 2018

1 reference

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Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation.

27 September 2018

1 reference

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

27 September 2018

1 reference

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Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity.

27 September 2018

1 reference

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Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

27 September 2018

1 reference

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Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

27 September 2018

1 reference

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Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.

27 September 2018

1 reference

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Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Frequency and Characteristics of Anxiety Among Patients With Alzheimer's Disease and Related Dementias

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Increased nuclear DNA oxidation in the brain in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333403

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25552414

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKU1356

1 reference

6 August 2017

1 reference

6 August 2017

1 reference