The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. (Q35107523)

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1 February 2020

title

The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake (English)

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3

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Maojun Yang

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Bao-Liang Song

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author name string

Jin-Hui Zhang

1

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1 February 2020

Liang Ge

2

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1 February 2020

Liqing Zhang

4

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1 February 2020

Hong-Hua Miao

5

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1 February 2020

Bo-Liang Li

6

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1 February 2020

language of work or name

English

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publication date

20 May 2011

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Journal of Biological Chemistry

1 February 2020

published in

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1 February 2020

volume

286

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1 February 2020

page(s)

25088-25097

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issue

28

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The structure of the NPC1L1 N-terminal domain in a closed conformation

1 February 2020

cites work

1 reference

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Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

9 July 2018

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Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers

9 July 2018

1 reference

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Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

9 July 2018

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Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase

9 July 2018

1 reference

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Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

9 July 2018

1 reference

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

9 July 2018

1 reference

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Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface

9 July 2018

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Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption

9 July 2018

1 reference

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

9 July 2018

1 reference

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Extracellular loop C of NPC1L1 is important for binding to ezetimibe

9 July 2018

1 reference

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The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

9 July 2018

1 reference

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Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

9 July 2018

1 reference

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Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

9 July 2018

1 reference

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Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease

9 July 2018

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Protein sensors for membrane sterols

9 July 2018

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Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137082

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137082

Niemann-Pick type C disease and intracellular cholesterol trafficking

9 July 2018

1 reference

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

9 July 2018

1 reference

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

9 July 2018

1 reference

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Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease

9 July 2018

1 reference

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Identification of HE1 as the second gene of Niemann-Pick C disease

9 July 2018

1 reference

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The structure and function of the Niemann-Pick C1 protein

9 July 2018

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9 July 2018

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Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B.

9 July 2018

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

9 July 2018

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

9 July 2018

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Rab11 regulates recycling through the pericentriolar recycling endosome

9 July 2018

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Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system

9 July 2018

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

9 July 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.244475

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

21 January 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.244475

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

21 January 2018

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Crossref

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NEW CONTRIBUTIONS IN STEROL METABOLISM

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21602275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The absorption and metabolism of sterols

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21602275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.244475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602275%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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1 February 2020

1 reference