The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo (Q35122947)

6 August 2017

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo (English)

1 reference

6 August 2017

Lei Huang

1

1 reference

6 August 2017

Zheng Yan

2

1 reference

6 August 2017

Xiaodong Liao

3

1 reference

6 August 2017

Yuan Li

4

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6 August 2017

Jie Yang

5

1 reference

6 August 2017

Zhu-Gang Wang

6

1 reference

6 August 2017

Yong Zuo

7

1 reference

6 August 2017

Hidehiko Kawai

8

1 reference

6 August 2017

Miriam Shadfan

9

1 reference

6 August 2017

Suthakar Ganapathy

10

1 reference

6 August 2017

Zhi-Min Yuan

11

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6 August 2017

language of work or name

English

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publication date

5 July 2011

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

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6 August 2017

108

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6 August 2017

29

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6 August 2017

12001-12006

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The p53 orchestra: Mdm2 and Mdmx set the tone

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

The first 30 years of p53: growing ever more complex

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

9 July 2018

Modes of p53 regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Blinded by the Light: The Growing Complexity of p53

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

MDMX: from bench to bedside

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

MDM2 interacts with MDMX through their RING finger domains

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

MDMX: a novel p53-binding protein with some functional properties of MDM2

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Tumor spectrum analysis in p53-mutant mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141917

The checkpoint monitoring chromosomal pairing in male meiotic cells is p53-independent

9 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21730163

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

mdmx is a negative regulator of p53 activity in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21730163

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1102309108

1 reference

6 August 2017

0 references

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6 August 2017

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