p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage (Q35123816)

6 August 2017

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage (English)

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6 August 2017

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C Chao

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6 August 2017

S Saito

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6 August 2017

J Kang

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6 August 2017

C W Anderson

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6 August 2017

E Appella

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6 August 2017

Y Xu

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6 August 2017

language of work or name

English

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publication date

1 September 2000

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6 August 2017

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6 August 2017

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6 August 2017

4967-4975

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describes a project that uses

6 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC314218/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

28 July 2018

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Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

28 July 2018

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DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

28 July 2018

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28 July 2018

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

28 July 2018

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

28 July 2018

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28 July 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

28 July 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

28 July 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

28 July 2018

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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

28 July 2018

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DNA damage induces phosphorylation of the amino terminus of p53

28 July 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

28 July 2018

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Regulation of ES cell differentiation by functional and conformational modulation of p53.

28 July 2018

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A model for p53-induced apoptosis

28 July 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

28 July 2018

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Regulation of p53 stability by Mdm2

28 July 2018

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Mdm2 promotes the rapid degradation of p53

28 July 2018

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p53, the cellular gatekeeper for growth and division

28 July 2018

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

28 July 2018

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Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

28 July 2018

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28 July 2018

p53: puzzle and paradigm

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Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement

28 July 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

28 July 2018

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Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells

28 July 2018

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Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

28 July 2018

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

28 July 2018

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

28 July 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

28 July 2018

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Tumor spectrum analysis in p53-mutant mice

28 July 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

28 July 2018

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LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells

28 July 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

28 July 2018

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Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

28 July 2018

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

28 July 2018

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Analysis of the gene coding for the murine cellular tumour antigen p53

28 July 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Mechanisms of switching on p53: a role for covalent modification?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

The complexity of p53 modulation: emerging patterns from divergent signals

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Dual roles of ATM in the cellular response to radiation and in cell growth control.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Thymocyte apoptosis induced by p53-dependent and independent pathways.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Essential role for p53-mediated transcription in E1A-induced apoptosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Radiation-induced cell cycle arrest compromised by p21 deficiency

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Negative feedback regulation of wild-type p53 biosynthesis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=314218

Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53

27 September 2018

1 reference

12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

12 December 2020

p53 transactivation domain mutant Q22, S23 is impaired for repression of promoters and mediation of apoptosis

1 reference

12 December 2020

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

12 December 2020

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

12 December 2020

Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies

1 reference

12 December 2020

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.18.4967

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6 August 2017

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6 August 2017

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