Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining (Q35132238)

6 August 2017

title

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining (English)

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6 August 2017

4

John J Miles

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6 August 2017

Kristin Ladell

2

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Awen Gallimore

Awen M Gallimore

11

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Andrew Godkin

Andrew J Godkin

12

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Scott R Burrows

Scott R Burrows

13

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David K. Cole

David K Cole

9

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Andrew K Sewell

Andrew K Sewell

15

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David A Price

David A Price

14

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author name string

Mathew Clement

1

1 reference

6 August 2017

Julia Ekeruche-Makinde

3

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6 August 2017

Emily S J Edwards

5

1 reference

6 August 2017

Garry Dolton

6

1 reference

6 August 2017

Tamsin Williams

7

1 reference

6 August 2017

Andrea J A Schauenburg

8

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6 August 2017

Sarah N Lauder

10

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6 August 2017

Linda Wooldridge

16

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6 August 2017

language of work or name

English

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publication date

15 June 2011

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6 August 2017

published in

Journal of Immunology

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6 August 2017

volume

187

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6 August 2017

issue

2

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6 August 2017

page(s)

654-663

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CD8 controls T cell cross-reactivity

6 August 2017

cites work

1 reference

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers

13 July 2018

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13 July 2018

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CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface

13 July 2018

1 reference

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Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists

13 July 2018

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13 July 2018

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Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

13 July 2018

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CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes

13 July 2018

1 reference

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The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

13 July 2018

1 reference

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Differential clustering of CD4 and CD3zeta during T cell recognition

13 July 2018

1 reference

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Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes

13 July 2018

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

13 July 2018

1 reference

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Role of CD4 and CD8 in T cell activation and differentiation

13 July 2018

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Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen

13 July 2018

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Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

13 July 2018

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Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: analysis by antibody blocking and selective trypsinization

13 July 2018

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Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.

13 July 2018

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Cell-cell adhesion mediated by CD8 and MHC class I molecules

13 July 2018

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

13 July 2018

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Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies

13 July 2018

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Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

13 July 2018

1 reference

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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

13 July 2018

1 reference

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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

13 July 2018

1 reference

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Association of CD8 with p56lck is required for early T cell signalling events.

13 July 2018

1 reference

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Epitope-specific binding of CD8 regulates activation of T cells and induction of cytotoxicity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus

13 July 2018

1 reference

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Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Coreceptor CD8-driven modulation of T cell antigen receptor specificity.

27 September 2018

1 reference

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Directed evolution of human T-cell receptors with picomolar affinities by phage display.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Thymus leukemia antigen (TL)-specific cytotoxic T lymphocytes recognize the 1/ 2 domain of TL free from antigenic peptides

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Monomeric class I molecules mediate TCR/CD3 epsilon/CD8 interaction on the surface of T cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145095

Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones

27 September 2018

1 reference

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Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

27 September 2018

1 reference

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Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

8 December 2018

1 reference

12 December 2020

Human CD8 co–receptor is strictly involved in MHC–peptide tetramer–TCR binding and T cell activation

1 reference

12 December 2020

Allogeneic and syngeneic class I MHC complexes drive the association of CD8 and TCR on 2C T cells

1 reference

12 December 2020

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

12 December 2020

OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release

1 reference

12 December 2020

Role of CD8 in staphylococcal enterotoxin B-mediated lysis by cytotoxic T lymphocytes

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12 December 2020

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1003941

1 reference

6 August 2017

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6 August 2017

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