Mitochondria in cell death: novel targets for neuroprotection and cardioprotection (Q35134634)

6 August 2017

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title

Mitochondria in cell death: novel targets for neuroprotection and cardioprotection (English)

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6 August 2017

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2

Guido Kroemer

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Mark Mattson

series ordinal

1

object named as

Mark P Mattson

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6 August 2017

1 May 2003

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Trends in Molecular Medicine

6 August 2017

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6 August 2017

9

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6 August 2017

196-205

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6 August 2017

5

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Mitochondria, AIF and caspases--rivaling for cell death execution.

6 August 2017

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Apoptosis: mitochondrial membrane permeabilization--the (w)hole story?

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Apoptotic and antiapoptotic mechanisms in stroke.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mitochondrial participation in ischemic and traumatic neural cell death

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Neuroprotection by the inhibition of apoptosis

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Evidence for the involvement of Par-4 in ischemic neuron cell death

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Excitotoxicity and mitochondria

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Apoptosis in neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Presenilin mutations and calcium signaling defects in the nervous and immune systems

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Accomplices to neuronal death

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Calpain and mitochondria in ischemia/reperfusion injury

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Caloric restriction restores the cardioprotective effect of preconditioning in the rat heart

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Differential actions of cardioprotective agents on the mitochondrial death pathway

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cardioprotective effects of diltiazem infusion in the perioperative period

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Protective effects of cyclosporin A from endotoxin-induced myocardial dysfunction and apoptosis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Extending myocardial viability during heart preservation with cyclosporine A.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Mitochondria as target for antiischemic drugs

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900046-7

7 January 2021

10.1016/S1471-4914(03)00046-7

Identifiers

DOI

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6 August 2017

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PubMed ID

12763524