Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease (Q34995120)

5 August 2017

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title

Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease (English)

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5 August 2017

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3

Mark P Mattson

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5 August 2017

Sic L Chan

1

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PubMed ID

12428810

5 August 2017

Katsutoshi Furukawa

series ordinal

2

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5 August 2017

1 January 2002

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5 August 2017

NeuroMolecular Medicine

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5 August 2017

2

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5 August 2017

2

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5 August 2017

167-196

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https://scigraph.springernature.com/pub.10.1385/nmm:2:2:167

5 August 2017

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cites work

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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12 December 2020

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

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12 December 2020

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12 December 2020

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

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12 December 2020

Identification of syntaxin 1A as a novel binding protein for presenilin-1.

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Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

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Structural correlates of cognition in dementia: quantification and assessment of synapse change.

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Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

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12 December 2020

Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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12 December 2020

Postsynaptic endocannabinoid release is critical to long-term depression in the striatum

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12 December 2020

A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos

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12 December 2020

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

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12 December 2020

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

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12 December 2020

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin

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12 December 2020

X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein

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12 December 2020

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

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12 December 2020

Calcium ionophore increases amyloid beta peptide production by cultured cells

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12 December 2020

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

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12 December 2020

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles.

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12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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12 December 2020

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

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12 December 2020

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

12 December 2020

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease.

1 reference

12 December 2020

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin

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12 December 2020

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

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12 December 2020

Stem cells and aging: expanding the possibilities

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12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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12 December 2020

Functional phenotype in transgenic mice expressing mutant human presenilin-1.

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Altered binding of mutated presenilin with cytoskeleton-interacting proteins

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12 December 2020

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

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12 December 2020

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

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12 December 2020

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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12 December 2020

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

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12 December 2020

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12 December 2020

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

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12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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12 December 2020

Regulated secretion of beta-amyloid precursor protein in rat brain

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12 December 2020

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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12 December 2020

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

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12 December 2020

Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis

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12 December 2020

Arbiter of differentiation and death: Notch signaling meets apoptosis

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12 December 2020

Physical and genetic interaction of filamin with presenilin in Drosophila.

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12 December 2020

Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex

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12 December 2020

beta-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus.

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12 December 2020

Long-term memory formation in the chick requires mobilization of ryanodine-sensitive intracellular calcium stores

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12 December 2020

Nuclear Notch1 signaling and the regulation of dendritic development

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12 December 2020

Isolation of human delta-catenin and its binding specificity with presenilin 1

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12 December 2020

The secreted form of the Alzheimer's beta-amyloid precursor protein stimulates a membrane-associated guanylate cyclase

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12 December 2020

beta-Amyloid-(1-40) increases long-term potentiation in rat hippocampus in vitro

1 reference

12 December 2020

LIN-12/Notch signaling: lessons from worms and flies

1 reference

12 December 2020

Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons.

1 reference

12 December 2020

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

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12 December 2020

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

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12 December 2020

Altered cell adhesion activity by pervanadate due to the dissociation of alpha-catenin from the E-cadherin.catenin complex

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12 December 2020

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

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12 December 2020

Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal

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12 December 2020

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

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12 December 2020

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

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12 December 2020

Plasticity of the hippocampus: adaptation to chronic stress and allostatic load.

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12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats

1 reference

12 December 2020

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice.

1 reference

12 December 2020

Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor

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12 December 2020

Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells

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12 December 2020

X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

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12 December 2020

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

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12 December 2020

A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation

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12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

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12 December 2020

Presenilin-mediated modulation of capacitative calcium entry

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12 December 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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12 December 2020

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

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12 December 2020

Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells

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12 December 2020

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

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12 December 2020

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

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12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

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12 December 2020

Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor

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12 December 2020

Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides

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12 December 2020

Senile plaques as aberrant sprout-stimulating structures.

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12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

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12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

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12 December 2020

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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12 December 2020

Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

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12 December 2020

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

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12 December 2020

Neuronal replacement in adult brain

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12 December 2020

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

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12 December 2020

SB203580, the p38 mitogen-activated protein kinase inhibitor blocks the inhibitory effect of beta-amyloid on long-term potentiation in the rat hippocampus

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12 December 2020

Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments.

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12 December 2020

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats.

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12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

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12 December 2020

4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11).

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12 December 2020

Molecular modification of N-cadherin in response to synaptic activity

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12 December 2020

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.

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12 December 2020

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

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12 December 2020

Oxidative stress induces neuronal death by recruiting a protease and phosphatase-gated mechanism

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12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

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12 December 2020

Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor-independent: it's offset by (-)huperzine A

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12 December 2020

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

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12 December 2020

Expression of presenilin-1 and Notch-1 receptor in human embryonic CNS.

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12 December 2020

Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease.

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12 December 2020

Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo

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12 December 2020

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

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12 December 2020

Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach.

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12 December 2020

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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12 December 2020

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

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12 December 2020

Interaction of presenilins with the filamin family of actin-binding proteins

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12 December 2020

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

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12 December 2020

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

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12 December 2020

Evidence for a physical interaction between presenilin and Notch

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12 December 2020

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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12 December 2020

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

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12 December 2020

Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat.

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12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

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12 December 2020

Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction

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12 December 2020

Age-dependent occurrence of synchronized population oscillation suggestive of a developing functional coupling between NMDA and ryanodine receptors in the neocortex

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12 December 2020

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

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12 December 2020

Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.

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12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

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12 December 2020

"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders

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12 December 2020

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

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12 December 2020

APP is required during an early phase of memory formation.

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12 December 2020

Nuclear signaling: a common function of presenilin substrates?

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12 December 2020

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons.

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12 December 2020

The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta

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12 December 2020

Evidence for synaptic apoptosis.

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12 December 2020

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

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12 December 2020

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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12 December 2020

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12 December 2020

Fast confocal imaging of calcium released from stores in dendritic spines.

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12 December 2020

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

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12 December 2020

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

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12 December 2020

Function and dysfunction of the presenilins

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12 December 2020

Roles of Wnt proteins in neural development and maintenance

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12 December 2020

Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments

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12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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12 December 2020

Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation

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12 December 2020

Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples

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12 December 2020

Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?

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12 December 2020

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

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12 December 2020

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

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12 December 2020

Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting

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12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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12 December 2020

Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus

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12 December 2020

Signaling through beta-catenin and Lef/Tcf

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12 December 2020

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

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12 December 2020

Apoptosis in neurodegenerative disorders

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12 December 2020

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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12 December 2020

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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12 December 2020

Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo.

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12 December 2020

Caspase and calpain substrates: roles in synaptic plasticity and cell death

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12 December 2020

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

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12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 December 2020

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

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12 December 2020

Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata.

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12 December 2020

beta-Amyloid protein-induced Alzheimer's disease animal model.

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12 December 2020

Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

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12 December 2020

Synaptic structure and function in transgenic APP mice.

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12 December 2020

Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain

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12 December 2020

Common and distinct fusion proteins in axonal growth and transmitter release

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12 December 2020

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.

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12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

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12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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12 December 2020

Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density

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12 December 2020

Direct association of presenilin-1 with beta-catenin

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12 December 2020

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

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12 December 2020

Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat

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12 December 2020

Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

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12 December 2020

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

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12 December 2020

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

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12 December 2020

Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function

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12 December 2020

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

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12 December 2020

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

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12 December 2020

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

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12 December 2020

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

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12 December 2020

Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.

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12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

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12 December 2020

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

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12 December 2020

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain.

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12 December 2020

Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation

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12 December 2020

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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12 December 2020

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

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12 December 2020

Tau and transgenic animal models

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12 December 2020

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

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12 December 2020

Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor

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12 December 2020

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice

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12 December 2020

Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism

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12 December 2020

Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

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12 December 2020

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

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12 December 2020

Synaptogenesis: insights from worm and fly.

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12 December 2020

beta-Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine

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12 December 2020

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

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12 December 2020

Presenilin I interaction with cytoskeleton and association with actin filaments.

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12 December 2020

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

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12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau.

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12 December 2020

Alpha-synuclein. Axonal transport, ligand interaction and neurodegeneration

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12 December 2020

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites.

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12 December 2020

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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12 December 2020

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

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12 December 2020

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

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12 December 2020

The cadherin superfamily at the synapse: more members, more missions.

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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12 December 2020

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

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12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

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12 December 2020

Functional interaction of beta-catenin with the transcription factor LEF-1

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12 December 2020

Mice deficient for the amyloid precursor protein gene.

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12 December 2020

Mechanisms of synaptic dysfunction in Alzheimer's disease.

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12 December 2020

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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12 December 2020

Presenilin mutations and calcium signaling defects in the nervous and immune systems

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12 December 2020

Presenilin affects arm/beta-catenin localization and function in Drosophila.

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12 December 2020

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease.

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults.

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12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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12 December 2020

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

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12 December 2020

Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

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12 December 2020

Synaptic plasticity in cortical systems

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12 December 2020

Synaptic and neuritic alterations during the progression of Alzheimer's disease

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12 December 2020

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

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12 December 2020

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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12 December 2020

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

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12 December 2020

Presenilins: molecular switches between proteolysis and signal transduction

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12 December 2020

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

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12 December 2020

Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

Variations on the Notch pathway in neural development

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12 December 2020

Identifiers

DOI

10.1385/NMM:2:2:167

1 reference

PubMed ID

12428810

Dimensions Publication ID

5 August 2017

0 references

1 reference

PubMed ID

12428810