p66(Shc): at the crossroad of oxidative stress and the genetics of aging (Q35134641)

6 August 2017

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title

p66(Shc): at the crossroad of oxidative stress and the genetics of aging (English)

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6 August 2017

Sally Purdom

1

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PubMed ID

12763525

6 August 2017

Qin M Chen

series ordinal

2

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6 August 2017

1 May 2003

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Trends in Molecular Medicine

6 August 2017

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6 August 2017

9

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6 August 2017

5

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6 August 2017

206-210

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The free radical theory of aging matures

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Gene expression profile of aging and its retardation by caloric restriction

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Mutations in PROP1 cause familial combined pituitary hormone deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Caloric restriction and aging: an update

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Oxidative stress, caloric restriction, and aging

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Evolution of Shc functions from nematode to human

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Shc signaling in differentiating neural progenitor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Not all Shc's roads lead to Ras

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https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Genetic pathways that regulate ageing in model organisms

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Aging, DNA methylation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

DNA methylation and atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

Extended longevity in mice lacking the insulin receptor in adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2803%2900048-0

7 January 2021

10.1016/S1471-4914(03)00048-0

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12763525