Negative selection--clearing out the bad apples from the T-cell repertoire (Q35136005)

6 August 2017

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title

Negative selection--clearing out the bad apples from the T-cell repertoire (English)

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6 August 2017

Ed Palmer

1

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6 August 2017

1 May 2003

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Nature Reviews Immunology

6 August 2017

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6 August 2017

3

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5

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6 August 2017

383-391

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Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production

6 August 2017

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Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

31 March 2020

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

31 March 2020

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Positive and negative selection of T cells

31 March 2020

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The thymus and central tolerance

31 March 2020

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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

31 March 2020

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Quantitative impact of thymic clonal deletion on the T cell repertoire

31 March 2020

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Using thymus anatomy to dissect T cell repertoire selection

31 March 2020

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The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire

31 March 2020

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31 March 2020

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Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

31 March 2020

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T-cell apoptosis detected in situ during positive and negative selection in the thymus

31 March 2020

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Central tolerance of T cells

31 March 2020

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Does T-cell tolerance require a dedicated antigen-presenting cell?

31 March 2020

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Tolerogenicity of thymic epithelium

31 March 2020

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CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

31 March 2020

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Intrathymic expression of genes involved in organ specific autoimmune disease

31 March 2020

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Aberrant expression of tissue-specific proteins in the thymus: a hypothesis for the development of central tolerance

31 March 2020

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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

31 March 2020

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

31 March 2020

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Self-antigen presentation by thymic stromal cells: a subtle division of labor

31 March 2020

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APECED: a monogenic autoimmune disease providing new clues to self-tolerance

31 March 2020

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Projection of an immunological self shadow within the thymus by the aire protein

31 March 2020

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T cell tolerance by clonal elimination in the thymus

31 March 2020

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The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

31 March 2020

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Negative selection in the thymus includes semimature T cells

31 March 2020

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Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.

31 March 2020

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Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

31 March 2020

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Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide

31 March 2020

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Evidence for a differential avidity model of T cell selection in the thymus

31 March 2020

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Positive and negative thymocyte selection induced by different concentrations of a single peptide

31 March 2020

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Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

31 March 2020

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T-cell-receptor affinity and thymocyte positive selection

31 March 2020

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Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

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Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

31 March 2020

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Several different cell surface molecules control negative selection of medullary thymocytes

31 March 2020

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Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells

31 March 2020

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Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivo

31 March 2020

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CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes

31 March 2020

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An essential role for gp39, the ligand for CD40, in thymic selection.

31 March 2020

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T cell receptor beta chain lacking the large solvent-exposed Cbeta FG loop supports normal alpha/beta T cell development and function in transgenic mice

31 March 2020

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Involvement of the TCR Cbeta FG loop in thymic selection and T cell function

31 March 2020

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Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection

31 March 2020

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Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation

31 March 2020

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CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

31 March 2020

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A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation

31 March 2020

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CD3 delta establishes a functional link between the T cell receptor and CD8

31 March 2020

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Positive selection through a motif in the alphabeta T cell receptor.

31 March 2020

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A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

31 March 2020

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Signaling life and death in the thymus: timing is everything

31 March 2020

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Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

31 March 2020

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

31 March 2020

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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

31 March 2020

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Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

31 March 2020

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Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

31 March 2020

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A LAT mutation that inhibits T cell development yet induces lymphoproliferation

31 March 2020

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

31 March 2020

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Identification of the minimal tyrosine residues required for linker for activation of T cell function

31 March 2020

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Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

31 March 2020

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

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A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily

31 March 2020

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

31 March 2020

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Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

31 March 2020

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Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis

31 March 2020

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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

31 March 2020

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Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

31 March 2020

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Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

31 March 2020

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Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

31 March 2020

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The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection

31 March 2020

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Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor

31 March 2020

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Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice

31 March 2020

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A role for Fas in negative selection of thymocytes in vivo

31 March 2020

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The thymus and negative selection

31 March 2020

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

31 March 2020

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Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

31 March 2020

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The suicide in the thymus, a twisted trail

31 March 2020

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The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

31 March 2020

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Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.

31 March 2020

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Caspase enzyme activity is not essential for apoptosis during thymocyte development

31 March 2020

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T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

31 March 2020

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

31 March 2020

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Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

31 March 2020

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

31 March 2020

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

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Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1085

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6 August 2017

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PubMed ID

12766760