Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty (Q35139549)

6 August 2017

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title

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty (English)

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6 August 2017

2

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6 August 2017

Boudewijn M T Burgering

series ordinal

1

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6 August 2017

1 June 2003

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Journal of Leukocyte Biology

6 August 2017

13

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based on heuristic

inferred from page(s)

published in

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6 August 2017

73

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6 August 2017

6

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6 August 2017

689-701

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6 August 2017

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Phosphoinositide 3-kinases in immunity: lessons from knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cell cycle and death control: long live Forkheads

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Five years on the wings of fork head

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The fork head domain: a novel DNA binding motif of eukaryotic transcription factors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Structural changes in the region directly adjacent to the DNA-binding helix highlight a possible mechanism to explain the observed changes in the sequence-specific binding of winged helix proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The interaction of DNA with the DNA-binding domain encoded by the Drosophila gene fork head.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

DNA recognition site analysis of Xenopus winged helix proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead transcription factors: key players in development and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

HNF-3 beta is essential for node and notochord formation in mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

TWH regulates the development of subsets of spinal cord neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Exposing the human nude phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Common mechanism for oncogenic activation of MLL by forkhead family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Chemosensory regulation of development in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Nuclear export receptors: from importin to exportin

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

14-3-3 proteins: regulation of subcellular localization by molecular interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Oxidative stress and life span determination in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The free radical theory of aging matures

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1202629

21 January 2018

Identifiers

DOI

10.1189/JLB.1202629

1 reference

6 August 2017

1 reference

PubMed ID

12773501