Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. (Q35156225)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19874086%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts (English)

1 reference

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11 February 2020

0 references

2

1 reference

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11 February 2020

Yoshiyuki Mochida

3

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11 February 2020

Paul B Yu

4

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11 February 2020

author name string

Nobuhiro Kamiya

1

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11 February 2020

Mitsuo Yamauchi

5

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11 February 2020

Henry M Kronenberg

6

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11 February 2020

Yuji Mishina

7

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11 February 2020

publication date

1 February 2010

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11 February 2020

number of pages

11

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Journal of Bone and Mineral Research

inferred from page(s)

published in

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11 February 2020

volume

25

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11 February 2020

issue

2

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11 February 2020

page(s)

200-210

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BMP type I receptor inhibition reduces heterotopic [corrected] ossification

11 February 2020

cites work

1 reference

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

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Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development

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Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

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Wnt signaling: a key regulator of bone mass

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

13 July 2018

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The role of growth factors and related agents in accelerating fracture healing

13 July 2018

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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

13 July 2018

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A Wnt canon orchestrating osteoblastogenesis

13 July 2018

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Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts.

13 July 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

13 July 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

13 July 2018

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Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

13 July 2018

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

13 July 2018

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13 July 2018

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Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins

13 July 2018

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Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

13 July 2018

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BMP receptor signaling is required for postnatal maintenance of articular cartilage

13 July 2018

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Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

13 July 2018

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Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

13 July 2018

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Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells

13 July 2018

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A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways.

13 July 2018

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Molecular recognition of BMP-2 and BMP receptor IA

13 July 2018

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

13 July 2018

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

13 July 2018

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13 July 2018

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BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

13 July 2018

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Physical stress by magnetic force accelerates differentiation of human osteoblasts

13 July 2018

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13 July 2018

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Control of osteoblast function and regulation of bone mass

13 July 2018

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Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

13 July 2018

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Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction

13 July 2018

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

13 July 2018

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The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

13 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

13 July 2018

1 reference

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

13 July 2018

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Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation

13 July 2018

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

13 July 2018

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

13 July 2018

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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

13 July 2018

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Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

13 July 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

13 July 2018

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

13 July 2018

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Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

13 July 2018

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

13 July 2018

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Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins

13 July 2018

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Generalized lacZ expression with the ROSA26 Cre reporter strain

13 July 2018

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Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

13 July 2018

1 reference

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Mechanism of activation of the TGF-beta receptor

13 July 2018

1 reference

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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

13 July 2018

1 reference

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Bone: formation by autoinduction

13 July 2018

1 reference

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The bone morphogenetic protein family and osteogenesis

13 July 2018

1 reference

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Receptors for the TGF-β family

13 July 2018

1 reference

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p38-Mitogen-activated protein kinase stimulated steroidogenesis in granulosa cell-oocyte cocultures: role of bone morphogenetic proteins 2 and 4.

13 July 2018

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

27 September 2018

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BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

27 September 2018

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Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

27 September 2018

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Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland.

27 September 2018

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

27 September 2018

1 reference

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BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

27 September 2018

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Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis

27 September 2018

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Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat

27 September 2018

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Generation of Bmpr/Alk3 conditional knockout mice.

27 September 2018

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Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

27 September 2018

1 reference

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

27 September 2018

1 reference

12 December 2020

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion

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12 December 2020

Evaluation of short-term healing following sustained delivery of osteoinductive agents in a rat femur drill defect model

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12 December 2020

Regulation of bone formation and vision by LRP5

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12 December 2020

Identifiers

DOI

10.1359/JBMR.090806

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19874086%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19874086%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

19874086

1 reference