Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer. (Q35166315)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21847362%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer (English)

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10 February 2020

2

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10 February 2020

author name string

Yi-Wei Wang

1

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10 February 2020

Kuen-Tyng Lin

3

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10 February 2020

Shu-Chen Lin

4

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10 February 2020

Jenq-Yuh Ko

5

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10 February 2020

Yuh-Shan Jou

6

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10 February 2020

publication date

1 August 2011

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10 February 2020

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10 February 2020

volume

13

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10 February 2020

issue

8

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10 February 2020

page(s)

704-715

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Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors

10 February 2020

cites work

1 reference

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Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors

28 July 2018

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28 July 2018

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Anaplastic lymphoma kinase: signalling in development and disease

28 July 2018

1 reference

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EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

A mouse model for EML4-ALK-positive lung cancer

28 July 2018

1 reference

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Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis

28 July 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

28 July 2018

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28 July 2018

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Identification of ALK as a major familial neuroblastoma predisposition gene

28 July 2018

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The anaplastic lymphoma kinase in the pathogenesis of cancer

28 July 2018

1 reference

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Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

28 July 2018

1 reference

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New molecularly targeted therapies for lung cancer

28 July 2018

1 reference

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Lung cancer in never smokers--a different disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

28 July 2018

1 reference

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Lung cancer: intragenic ERBB2 kinase mutations in tumours

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

High frequency of mutations of the PIK3CA gene in human cancers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Expression of the ALK tyrosine kinase gene in neuroblastoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

A Ki-1 (CD30)-positive human cell line (Karpas 299) established from a high-grade non-Hodgkin's lymphoma, showing a 2;5 translocation and rearrangement of the T-cell receptor beta-chain gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

p53: a frequent target for genetic abnormalities in lung cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

EML4-ALK: honing in on a new target in non-small-cell lung cancer.

27 September 2018

1 reference

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Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas.

27 September 2018

1 reference

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Oncogenic mutations of ALK kinase in neuroblastoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status.

27 September 2018

1 reference

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Molecular genetics of lung cancer in people who have never smoked

27 September 2018

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Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond

27 September 2018

1 reference

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Characterizing the cancer genome in lung adenocarcinoma

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Missense mutations of the BRAF gene in human lung adenocarcinoma.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Chromosomal imbalances in human lung cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156661

Oncogenic mutations of PIK3CA in human cancers

27 September 2018

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12 December 2020

BRAF and RAS mutations in human lung cancer and melanoma

1 reference

12 December 2020

Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient

1 reference

12 December 2020

Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1

1 reference

12 December 2020

Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer

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12 December 2020

Identifiers

DOI

10.1593/NEO.11222

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21847362%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21847362%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

21847362

1 reference