Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. (Q40160132)

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27 December 2019

title

Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway (English)

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27 December 2019

1

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27 December 2019

Robert Bucki

7

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Pawel Krzysztof Wlodarski

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8

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author name string

Kasprzycka M

2

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27 December 2019

Liu X

3

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27 December 2019

El-Salem M

4

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27 December 2019

Halasa K

5

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27 December 2019

Raghunath PN

6

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27 December 2019

Wasik MA

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language of work or name

English

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publication date

12 March 2007

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27 December 2019

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27 December 2019

volume

26

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issue

38

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page(s)

5606-5614

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

27 December 2019

cites work

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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma

21 January 2018

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AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha

21 January 2018

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7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

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7 January 2021

Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

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7 January 2021

Tsc2 is not a critical target of Akt during normal Drosophila development

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7 January 2021

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

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7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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7 January 2021

Upstream and downstream of mTOR

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7 January 2021

Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

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7 January 2021

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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7 January 2021

Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses

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7 January 2021

The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

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7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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7 January 2021

Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

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7 January 2021

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

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7 January 2021

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

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7 January 2021

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

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7 January 2021

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

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7 January 2021

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

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7 January 2021

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

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7 January 2021

Involvement of a rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro

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7 January 2021

Ras, PI(3)K and mTOR signalling controls tumour cell growth

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7 January 2021

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

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7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

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7 January 2021

Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway

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7 January 2021

Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid

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7 January 2021

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

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7 January 2021

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

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7 January 2021

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

1 reference

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7 January 2021

Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.

1 reference

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7 January 2021

Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210346

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17353907%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 December 2019

1014228369

0 references

1 reference