Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C. (Q35167848)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21708114%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C (English)

1 reference

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6 February 2020

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2

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6 February 2020

author name string

Sharon Zhou

1

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6 February 2020

Robert McGlynn

3

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6 February 2020

Gloria Stephney

4

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6 February 2020

Kostantin Dobrenis

5

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6 February 2020

Marie T Vanier

6

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6 February 2020

Steven U Walkley

7

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6 February 2020

language of work or name

English

0 references

publication date

2 June 2011

1 reference

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The American Journal of Pathology

6 February 2020

published in

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6 February 2020

volume

179

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6 February 2020

issue

2

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6 February 2020

page(s)

890-902

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GD3- and O-acetylated GD3-gangliosides in the GM2 synthase-deficient mouse brain and their immunohistochemical localization

6 February 2020

cites work

1 reference

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

28 July 2018

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Neuropathology of the Mcoln1(-/-) knockout mouse model of mucolipidosis type IV.

28 July 2018

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Secondary lipid accumulation in lysosomal disease

28 July 2018

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Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

28 July 2018

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Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases

28 July 2018

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Pathogenic mechanisms in lysosomal disease: a reappraisal of the role of the lysosome

28 July 2018

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Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease

28 July 2018

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28 July 2018

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Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

28 July 2018

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Secondary accumulation of gangliosides in lysosomal storage disorders

28 July 2018

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Model systems, lipid rafts, and cell membranes

28 July 2018

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Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

28 July 2018

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Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution

28 July 2018

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AMPA Receptor Trafficking at Excitatory Synapses

28 July 2018

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Neurobiology and cellular pathogenesis of glycolipid storage diseases

28 July 2018

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Salvage pathways in glycosphingolipid metabolism

28 July 2018

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Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease

28 July 2018

1 reference

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Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations

28 July 2018

1 reference

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Identification of HE1 as the second gene of Niemann-Pick C disease

28 July 2018

1 reference

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Lipid changes in Niemann-Pick disease type C brain: personal experience and review of the literature

28 July 2018

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A biotinylated perfringolysin O derivative: a new probe for detection of cell surface cholesterol

28 July 2018

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

28 July 2018

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Development regulation of ganglioside metabolism

28 July 2018

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Two procedures to remove polar contaminants from a crude brain lipid extract by using prepacked reversed-phase columns

28 July 2018

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28 July 2018

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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

28 July 2018

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GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice

27 September 2018

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27 September 2018

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27 September 2018

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27 September 2018

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Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders

27 September 2018

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27 September 2018

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27 September 2018

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A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

27 September 2018

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Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent

27 September 2018

1 reference

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Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons

27 September 2018

1 reference

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Receptor trafficking and the plasticity of excitatory synapses.

27 September 2018

1 reference

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Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.

27 September 2018

1 reference

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Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157170

Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157170

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157170

Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21708114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alleviation of neuronal ganglioside storage does not improve the clinical course of the Niemann-Pick C disease mouse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21708114

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.AJPATH.2011.04.017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21708114%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21708114%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference