Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms (Q35186358)

7 August 2017

1 reference

title

Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms (English)

1 reference

7 August 2017

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Alexandre A da Silva

3

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author name string

John E Hall

1

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7 August 2017

Jussara M do Carmo

2

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7 August 2017

Zhen Wang

4

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7 August 2017

Michael E Hall

5

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7 August 2017

1 March 2015

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7 August 2017

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7 August 2017

116

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7 August 2017

991-1006

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7 August 2017

6

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Chronic central nervous system MC3/4R blockade attenuates hypertension induced by nitric oxide synthase inhibition but not by angiotensin II infusion

7 August 2017

1 reference

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Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

13 July 2018

1 reference

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Role of aldosterone blockade in resistant hypertension

13 July 2018

1 reference

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Natriuretic peptides in cardiometabolic regulation and disease

13 July 2018

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The brain melanocortin system, sympathetic control, and obesity hypertension

13 July 2018

1 reference

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The pathophysiology of hypertension in patients with obesity

13 July 2018

1 reference

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Catheter-based radiorefrequency renal denervation lowers blood pressure in obese hypertensive dogs

13 July 2018

1 reference

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A controlled trial of renal denervation for resistant hypertension

13 July 2018

1 reference

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Obesity, hypertension, and chronic kidney disease

13 July 2018

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Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems

13 July 2018

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13 July 2018

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Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

13 July 2018

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Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin

13 July 2018

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Selective leptin resistance revisited

13 July 2018

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Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway

13 July 2018

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Differential control of metabolic and cardiovascular functions by melanocortin-4 receptors in proopiomelanocortin neurons.

13 July 2018

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Hypertension: physiology and pathophysiology

13 July 2018

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Neural melanocortin receptors in obesity and related metabolic disorders

13 July 2018

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The sympathetic nervous system in obesity hypertension

13 July 2018

1 reference

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Relative atrial natriuretic peptide deficiency and inadequate renin and angiotensin II suppression in obese hypertensive men.

13 July 2018

1 reference

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Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin

13 July 2018

1 reference

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Structural renal changes in obesity and diabetes

13 July 2018

1 reference

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Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons

13 July 2018

1 reference

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The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects

13 July 2018

1 reference

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Sympathetic nervous system and hypertension

13 July 2018

1 reference

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Pathophysiology of human visceral obesity: an update

13 July 2018

1 reference

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Role of leptin and central nervous system melanocortins in obesity hypertension

13 July 2018

1 reference

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Hyperaldosteronism as a common cause of resistant hypertension

13 July 2018

1 reference

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Adipose tissue renin-angiotensin-aldosterone system (RAAS) and progression of insulin resistance

13 July 2018

1 reference

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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

13 July 2018

1 reference

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The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome

13 July 2018

1 reference

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Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats

13 July 2018

1 reference

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Systemic and renal-specific sympathoinhibition in obesity hypertension

13 July 2018

1 reference

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Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study

13 July 2018

1 reference

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Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons

13 July 2018

1 reference

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Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors

13 July 2018

1 reference

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Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation

13 July 2018

1 reference

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Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis

13 July 2018

1 reference

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Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus

13 July 2018

1 reference

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Melanocortin signalling and the regulation of blood pressure in human obesity

13 July 2018

1 reference

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Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events

13 July 2018

1 reference

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Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins

13 July 2018

1 reference

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The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

13 July 2018

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Natriuretic peptides and cardiovascular damage in the metabolic syndrome: molecular mechanisms and clinical implications

13 July 2018

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STUDIES ON EXPERIMENTAL HYPERTENSION : II. THE EFFECT OF RESECTION OF SPLANCHNIC NERVES ON EXPERIMENTAL RENAL HYPERTENSION

13 July 2018

1 reference

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Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.

13 July 2018

1 reference

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Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system

13 July 2018

1 reference

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The adipose renin-angiotensin system: role in cardiovascular disease.

13 July 2018

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Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

13 July 2018

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Reconsidering the roles of the mineralocorticoid receptor

13 July 2018

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Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney

13 July 2018

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13 July 2018

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13 July 2018

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Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats

13 July 2018

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Genetics of Obesity in Humans

13 July 2018

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Studies on the physiological functions of the melanocortin system

13 July 2018

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Molecular and anatomical determinants of central leptin resistance

13 July 2018

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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

13 July 2018

1 reference

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Obesity and hypertension: two epidemics or one?

13 July 2018

1 reference

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Impact of obesity on plasma natriuretic peptide levels

13 July 2018

1 reference

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Is obesity a major cause of chronic kidney disease?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration.

13 July 2018

1 reference

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Minireview: Adiposity, Inflammation, and Atherogenesis

13 July 2018

1 reference

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The kidney, hypertension, and obesity

13 July 2018

1 reference

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Mechanisms of obesity-associated cardiovascular and renal disease

13 July 2018

1 reference

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Chronic cardiovascular and renal actions of leptin: role of adrenergic activity

13 July 2018

1 reference

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Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

13 July 2018

1 reference

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Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

13 July 2018

1 reference

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The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

13 July 2018

1 reference

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The altered structure of renal papillary outflow tracts in obesity

13 July 2018

1 reference

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

13 July 2018

1 reference

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Mechanisms of hypertension and kidney disease in obesity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Pathophysiological role of leptin in obesity-related hypertension.

13 July 2018

1 reference

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Central nervous system control of food intake

13 July 2018

1 reference

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Overweight and hypertension : a 2-way street?

13 July 2018

1 reference

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Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

13 July 2018

1 reference

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Relationship between muscle sympathetic nerve activity and plasma leptin concentration

13 July 2018

1 reference

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Lisinopril versus hydrochlorothiazide in obese hypertensive patients: a multicenter placebo-controlled trial. Treatment in Obese Patients With Hypertension (TROPHY) Study Group

13 July 2018

1 reference

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Receptor-mediated regional sympathetic nerve activation by leptin.

13 July 2018

1 reference

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Mechanisms of abnormal renal sodium handling in obesity hypertension

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

13 July 2018

1 reference

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Autonomic nervous system activity in weight gain and weight loss

13 July 2018

1 reference

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Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity.

13 July 2018

1 reference

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Heart rate variability as a measure of autonomic function during weight change in humans

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

The relationship of body mass and fat distribution with incident hypertension: observations from the Dallas Heart Study

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Experimental hyperleptinemia acutely increases vasoconstrictory sympathetic nerve activity in healthy humans

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Efficacy of spironolactone therapy in patients with true resistant hypertension.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Renal sympathetic-nerve ablation for uncontrolled hypertension

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Modulation of blood pressure by central melanocortinergic pathways

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Body mass index and risk for end-stage renal disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo-controlled trial

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Role of selective leptin resistance in diet-induced obesity hypertension.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

AT1-receptor antagonism reverses the blood pressure elevation associated with diet-induced obesity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Measures of obesity are associated with vascular stiffness in young and older adults

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Intracellular mechanisms involved in leptin regulation of sympathetic outflow

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Distribution of renal medullary hyaluronan in lean and obese rabbits.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

The effect of weight loss intervention on antihypertensive medication requirements in the hypertension Optimal Treatment (HOT) study.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Chronic leptin infusion increases arterial pressure.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Intra-abdominal pressure, sagittal abdominal diameter and obesity comorbidity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Effects of captopril on sympathetic activity, lipid and carbohydrate metabolism in a model of obesity-induced hypertension in dogs.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Increased hyaluronic acid in the inner renal medulla of obese dogs.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Hemodynamic alterations in hypertensive obese rabbits.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Cardiovascular Actions of Leptin in the Subfornical Organ are Abolished by Diet-Induced Obesity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Association of anthropometric obesity measures with chronic kidney disease risk in a non-diabetic patient population

8 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Melanocortin-4 Receptor Activation Stimulates Hypothalamic Brain-Derived Neurotrophic Factor Release to Regulate Food Intake, Body Temperature and Cardiovascular Function

8 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4363087

Sustained Sympathetic and Blood Pressure Reduction 1 Year After Renal Denervation in Patients With Resistant Hypertension

8 December 2018

1 reference

12 December 2020

Obesity-induced hypertension. Renal function and systemic hemodynamics

1 reference

12 December 2020

Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity

1 reference

12 December 2020

Incidence and precursors of hypertension in young adults: the Framingham Offspring Study

1 reference

12 December 2020

Reduced parasympathetic control of heart rate in obese dogs

1 reference

12 December 2020

Sympathetic function in human carriers of melanocortin-4 receptor gene mutations

1 reference

12 December 2020

Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series

1 reference

12 December 2020

Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation

1 reference

12 December 2020

Differential effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension: a double-blind, placebo-controlled cross-over trial

1 reference

12 December 2020

Functional and structural changes in the kidney in the early stages of obesity

1 reference

12 December 2020

A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding

1 reference

12 December 2020

Body mass index and blood pressure in Korean men and women: the Korean National Blood Pressure Survey

1 reference

12 December 2020

Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet

1 reference

12 December 2020

Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin

1 reference

12 December 2020

Increased renal Na-K-ATPase, NCC, and beta-ENaC abundance in obese Zucker rats

1 reference

12 December 2020

Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin

1 reference

12 December 2020

Neural mechanisms in human obesity-related hypertension

1 reference

12 December 2020

Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects

1 reference

12 December 2020

Role of the renal nerves in one-kidney, one clip hypertension in rats

1 reference

12 December 2020

10.1161/CIRCRESAHA.116.305697

Identifiers

DOI

1 reference

7 August 2017

1 reference

7 August 2017

1 reference